Replies

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Mazzotti Reaction:

Drug reaction with eosinophilia and systemic
symptoms (DRESS) syndrome, also known as drug induced hypersensitivity syndrome, is a rare, potentially life-threatening adverse drug reaction with an
estimated mortality rate up to 10%.1 We report a case
of DRESS syndrome

caused by ivermectin,

which, to our knowledge, has not been reported previously;

DRESS syndrome is a severe adverse drug reaction
that typically occurs 2 to 6 weeks after initiation of
the offending drug. DRESS syndrome is characterized by generalized exanthema with facial swelling,
fever, lymphadenopathy, leukocytosis with eosinophilia, and

internal organ involvement with liver or
renal dysfunction.2 Diagnosis of DRESS syndrome is established by applying the RegiSCAR scoring system shown in Table I.
3,4

The most common causative
drugs include antiepileptics, allopurinol, antimicrobial sulfonamides, minocycline, and vancomycin.2
An association with reactivation of viruses of the
herpes family (human herpesvirus-6, Epstein-Barr
virus, and cytomegalovirus) has also been reported.

To our knowledge, this is the first reported case
adding ivermectin to the list of drugs causing DRESS
syndrome.

https://www.jaadcasereports.org/article/S2352-5126(18)30118-8/pdf#:~:text=When%20ivermectin%20is%20used%20to%20treat%20%EF%AC%81larial%20parasites%2C,of%20the%20administration%20of%20ivermectin%20and%20are%20likely

And,

Ivermectin Side Effects: Common, Severe, Long Term - Drugs.com
https://www.drugs.com/sfx/ivermectin-side-effects.html

Also,

https://en.wikipedia.org/wiki/Mazzotti_reaction