Here's what libh8er's article refuting this said:
https://sciencebasedmedicine.org/antivaxxers-misrepresent-a-study-to-falsely-claim-that-covid-19-vaccines-cause-cancer/
"Second, the mRNA in the Moderna and Pfizer/BioNTech vaccines does not undergo any splicing, both of which occur in the nucleus. The mRNA sequences in these vaccines is a complete mRNA sequence for the SARS-CoV-2 spike protein and needs no splicing before transcription. Indeed, it really wouldn’t make any sense at all to include in a vaccine an mRNA that requires splicing, as that’s an extra step where things could go wrong and that doesn’t provide any countervailing advantage to make it worthwhile to do. Basically, when you are trying to get eukaryotic cells (as in human cells) to produce a protein from an RNA, keeping the design of the mRNA as simple as possible is best. Use the RNA sequence encoding the protein you want to produce, tack on whatever regulatory sequences to the coding sequence in order to drive expression of the protein, and get as much of the RNA into the cytoplasm to encounter as many ribosomes and churn out as much protein as possible before the RNA, unstable molecule that it is, inevitably degrades. In other words, no splicing or truncated proteins, even if the proteins being produced were even relevant to cancer, which the coronavirus spike protein is not."
Translation into English:
"Mayr {the Sloan-Kettering guy} posited that errors in preprocessing the mRNA and shuffling it in and out of the nucleus, may lead to interference with proteins, and thence to cancer; but the mRNA injections come "ready made" and don't need to make it to the nucleus; and the effect of interfering with proteins is in general limited to the proteins encoded for specifically by that mRNA, and the mRNA for anti-COVID jabs only makes spike proteins, not other cell proteins that help prevent cancer, so no biggie"
Thx to libh8r on calling me out on jumping the gun; and more, providing a link with actual content rather than just cartoons of Karens discussing why wearing masks is important.
ThankQ, G_W !
grey_whiskers wrote:
“I had a tangle with another user (libh8er) on this one; the source is misinterpreting / overstating what Sloan-Kettering said.
Here’s what libh8er’s article refuting this said:
“Second, the mRNA in the Moderna and Pfizer/BioNTech vaccines does not undergo any splicing, both of which occur in the nucleus. The mRNA sequences in these vaccines is a complete mRNA sequence for the SARS-CoV-2 spike protein and needs no splicing before transcription. Indeed, it really wouldn’t make any sense at all to include in a vaccine an mRNA that requires splicing, as that’s an extra step where things could go wrong and that doesn’t provide any countervailing advantage to make it worthwhile to do. Basically, when you are trying to get eukaryotic cells (as in human cells) to produce a protein from an RNA, keeping the design of the mRNA as simple as possible is best. Use the RNA sequence encoding the protein you want to produce, tack on whatever regulatory sequences to the coding sequence in order to drive expression of the protein, and get as much of the RNA into the cytoplasm to encounter as many ribosomes and churn out as much protein as possible before the RNA, unstable molecule that it is, inevitably degrades. In other words, no splicing or truncated proteins, even if the proteins being produced were even relevant to cancer, which the coronavirus spike protein is not.”
Translation into English:
“Mayr {the Sloan-Kettering guy} posited that errors in preprocessing the mRNA and shuffling it in and out of the nucleus, may lead to interference with proteins, and thence to cancer; but the mRNA injections come “ready made” and don’t need to make it to the nucleus; and the effect of interfering with proteins is in general limited to the proteins encoded for specifically by that mRNA, and the mRNA for anti-COVID jabs only makes spike proteins, not other cell proteins that help prevent cancer, so no biggie”
Thx to libh8r on calling me out on jumping the gun; and more, providing a link with actual content rather than just cartoons of Karens discussing why wearing masks is important.”