Posted on 04/08/2021 2:30:16 PM PDT by ransomnote
Thanks for the ping!
Had an English tour guide for a couple of days way back when in London. He always made it a point to call him YOUR King George III as if he was our rightful King. It was cute.
It is generally thought that the sole function of viral membrane fusion proteins is to allow the viruses to bind to the host cells for the purpose of viral entry into the cells, so that the genetic materials can be released and the viral replication and amplification can take place.
However, recent observations suggest that the SARS-CoV-2 spike protein can by itself trigger cell signaling that can lead to various biological processes. It is reasonable to assume that such events, in some cases, result in the pathogenesis of certain diseases.
Our laboratory only tested the effects of the SARS-CoV-2 spike protein in lung vascular cells and those implicated in the development of PAH. However, this protein may also affect the cells of systemic and coronary vasculatures, eliciting other cardiovascular diseases such as coronary artery disease, systemic hypertension, and stroke. In addition to cardiovascular cells, other cells that express ACE2 have the potential to be affected by the SARS-CoV-2 spike protein, which may cause adverse pathological events.
Thus, it is important to consider the possibility that the SARS-CoV-2 spike protein produced by the new COVID-19 vaccines triggers cell signaling events that promote PAH, other cardiovascular complications, and/or complications in other tissues/organs in certain individuals (Figure 3). We will need to monitor carefully the long-term consequences of COVID-19 vaccines that introduce the spike protein into the human body.
Furthermore, while human data on the possible long-term consequences of spike protein-based COVID-19 vaccines will not be available soon, it is imperative that appropriate experimental animal models are employed as soon as possible to ensure that the SARS-CoV-2 spike protein does not elicit any signs of the pathogenesis of PAH or any other chronic pathological conditions.
= = = = = = = = = =
Well, lookie here. Might be a coincidence, might be misunderstanding on my part.
But, following up on this old post from FReeper Cathi --
"The SARS-CoV-2 spike protein without the rest of the viral components has also been shown to activate cell signaling by Patra et al. [29]. The authors reported that the full-length SARS-CoV-2 spike protein expressed by the means of transient transfection, either in the human lung alveolar epithelial cell line A549 or in the human liver epithelial cell line Huh7.5, activated NF-κB and AP-1 transcription factors as well as p38 and ERK mitogen-activated protein kinases, releasing interleukin-6. This cell signaling cascade was found to be triggered by the SARS-CoV-2 spike protein downregulating the ACE2 protein expression, subsequently activating the angiotensin II type 1 receptor [29]. These experiments using transient transfection may reflect the intracellular effects of the spike protein that could be triggered by the RNA- and viral vector-based vaccines.
These results collectively reinforce the idea that human cells are sensitively affected by the extracellular and/or intracellular spike proteins though the activation of cell signal transduction."
I replied:
OK, so what proteins are preferentially (or increasingly) synthesized by the cell upon binding by the spike protein? What are their systemic downstream effects, in those not suffering insult to the lungs by a real c00f infection?
...activated NF-κB and AP-1 transcription factors as well as p38 and ERK mitogen-activated protein kinases,...
Well, The NF-κB transcription factor was discovered 30 years ago and has since emerged as the master regulator of inflammation and immune homeostasis. It achieves this status by means of the large number of important pro- and antiinflammatory factors under its transcriptional control.
So I tried Goolaging for "NF-κB transcription factor clotting" and found this old paper:
NF-κB Transcription Factor p50 Critically Regulates Tissue Factor in Deep Vein Thrombosis*
NF-κB transcription factors regulate the expression of tissue factor (TF), a principal initiator of the coagulation cascade. Dominant among them is the p50/p65 heterodimer.
Now, I fully admit, I notice this is an old paper and might have been superseded, or disproven. The paper was working on Mice, and not people; and had a disclaimer as such in its own discussion section. And, for all I know, I misread it and got it ass-backwards. But the fact there seems to be an association, between a protein produced, when you ring the doorbell of the ACE2 receptor, and Deep Vein Thrombosis; and that both the Coof and mRNA jabs produce spike protein which interact with the ACE2 receptor; and that both the Coof and mRNA jabs cause clotting issues (and DVT has been presented in the literature as an occult ("hidden" not "demonic") symptom of Coof infection, is enough to make me ask if we have any cardiologists / hematologists / thrombologists here, who can comment from a more informed perspective?
I picture Ukraine as a mail box down at the post office to which the U.S. government regularly sends millions of dollars in cash, and to which a select few have a key.
PSA to all vaxxed FReepers and FReeQs.
I spoke with a mcrobiologist who said the flu vaccines in the fall would worsen the problem being investigated in Grey_Whisker’s post here:
https://freerepublic.com/focus/chat/3948996/posts?page=2243#2243
This article is over my head (WAY too much detail for my background) but the sections on Platelets and on Sepsis as an Example of an Acute Thrombo-Inflammatory Disease State, look interesting.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369217/
wowzer from prophet Timothy Dixon
04/09/21 The Beast of, will be destroyed/ President Donald Trump will return the high SET/ Apr 15, 2021
https://www.youtube.com/watch?v=pb38k88xHRk
Beast out of sea. Tunneling. With eyes. Underneath Wash, Ore, Calif, NV, UT, AZ, NM, CO, KA, OK, TN, Atlanta, GA, NC, PA, RI, MN, WI, IL, CT, MA, NH, VA, NY, NJ, New Eng states, dug a hole. Tunnel underneath from state to state. Beast tuned back underground disappeared, hiding. Where did the beast go? What you see has passed and already done. Hidden beast dug tunnels.
Hidden until an appointed time. Not to every state. People could climb into tunnels from surface in cities. Nashville, Atlanta, Seattle, Portlad. NYC, Wash DC, OH valley. Could see traffic of people in tunnels, hidden. Above heavens, trumpet blew. Angel said, it’s time for the saints to possess the kingdom. Churches/people awakened. Praying. Seeking God. Beyond natural salvation, praying for America. Stood up. Power given to some as they prayed. Saw “a people of the saints”. Revival. Some on fire, doorway to God.
Before July. God’s gonna move.
Tunnel, like a great flood washing tunnel highway, satanic highway. Place of AC spirit. Great reset. Wants to stomp out Christianity, books, mind, kids, guns. Crumblin tunnel. Fallin apart. Voice from heaven sound like thunder. Power. Word of God. Angels, hurt not this nation until the time is fulfilled, Lord spoke, I will do what no one will do. Donald Trump will take the high seat above the storm. Death across the nation to do evil, sicknesses. God’s hand turned, the people that were doing satanic attack to kill hundreds and thousands, God’s got your number coming, your time’s coming. Sickness hit the evil bunch in offices. God will save this country.
Sicknesses go out, hands of God go out thru land. God, turned high officials, laughed mocked God’s people. Evil ones, cry for God to have mercy. God will pour out his judgement on the wicked trying to stop the great awakening. Donald Trump should get his stuff packed.
God’s gonna show those who think there is no God. Fulton county. They’ll have a choice.
Repent or perish.
Are similar problems to be expected in the fall, for those who are unvaccinated, who have come by their immunity naturally?
I think he will. I think he MUST. Otherwise, there will be no country to come back TO.
Personal belief is that even if he were to say to himself "F*** it, I'm done. I've endured enough", he wouldn't exit the stage without making some kind of an announcement. He's never been the type to just leave 80 million+ Americans hanging.
Also, anyone have any idea what the greatly increased amount of military air traffic means? Monkeywerx pointed out that there appears to be a good amount of recent activity involving Guantanamo Bay.
Don't you mean "A certain number of deaths?
Or are the dead ones cretins? :-)
~~~~~~~~~~~~~~~~
Unknown. But frankly willing vaccination with Covid-19 is not going well and those who control the flu vaccine made just 'supplement it' to get the job done.
As long as China's Fauci/Biden/Deeps state drives the process, I won't get a flu vaccine and will avoid needles in arms when possible. I trust my local physicians, but they are being leveraged and lied to also, so who knows what's really in the flu vax this year?
https://informedconsentdefense.org/
It looks like the Covid-19 vaccine is not the first weaponized vax. It seems like the data in this legal filing indicate the 'problem' started around 1994 (unleashed with the election of Bill Clinton?).
I'll just put a few images below, but there are PDF's of images indicating vaccinations began making us sicker shortly after 1994.
Health Freedom Litigators
Greg Glaser & Ray Flores
Case Overview
On February 22, 2021 we appeared in Federal Court to request a court order (1) recognizing the role of vaccines in the national health epidemic, (2) upholding that control group studies of vaccinated v. unvaccinated are scientifically advantageous, and (3) exempting all persons from mandatory vaccination.
Click the images below to view our court documents, proving for example that unvaccinated adults enjoy 1,248% better health than vaccinated. And unvaccinated children enjoy 1,099% better health than vaccinated.
Click here to read our Verified Court Petition. The next step in our case is an appeal with the 9th Circuit.
Summary Report, Full Report, National Security Report.
Our Case Documents
Click the image to view our many graphs proving the unvaccinated control group is exponentially healthier than the vaccinated.
Here’s hoping your right about Trump.
I forgot to mention that i saw a statistic that said those vaccinated for flu in 2018-2019 season were 38% more likely to be infected with Covid-19.
Hey there! Just had the pleasure of watching that Jim Jordan brilliance and fire on Live From Studio 6B on America’s Voice channel. They played the entire thing. Did I mention his sister, and brother in law are members of the church I attend? 😁 Both are wonderful people. Have not met Jim yet (lives in different state).
I’ve got to look up Max Taquet papers.
Yes, Trump would not leave us to be devoured by the wolves. He will return.
As for:
Monkeywerx pointed out that there appears to be a good amount of recent activity involving Guantanamo Bay.
::::::
I like it!
“Clearly the focus of Fauci and others is not on protecting the public, but instead serves China.”
The vaccines are built on lies too (e.g., they used the PCR to ‘prove’ their vaccines work).”
Thanks for your well thought out reply. The whole covid story is difficult to believe, given the actions of the politicians and, especially the medical establishment, whose actions have been totally different from any earlier treatment protocol (or lack there of) for a disease.
EP.132 Cathy O’Brien MK Ultra, the Media, the Agencies, the people and more...
1 day ago RightOnRadio
“World Famous Whistle-Blower MK Ultra Survivor takes us into deep understanding of Mind Control. How is it being used on the masses and how to set your mind free.”
https://vimeo.com/user113361026
They used to put that crap on islands for a reason!
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.