From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031366/
The extraskeletal actions of vitamin D are legion as befits a molecule (1,25(OH)2D, the active metabolite of vitamin) whose receptor is found in nearly all cells, many of which also contain the enzyme (CYP27B1) that can produce 1,25(OH)2D in the same cell. Indeed, thousands of cellular and animal studies indicate that vitamin D signaling has a profound effect on most physiologic processes, including cancer prevention, improved cardiovascular function, diabetes prevention, prevention of obesity, improved muscle function, enhanced barrier function of the skin, hair follicle cycling, and prevention of immune related diseases. Indeed, association studies in humans have linked vitamin D deficiency to diseases resulting from disruption of these physiologic processes. However, large RCTs that clearly demonstrate the promising potential of vitamin D in the prevention and treatment of these diseases have either not been done or have produced mixed results. Part of the problem relates to lack of pharmaceutical support for large RCTs involving a drug (i.e., vitamin D) that cannot be patented, or the inability to give high enough doses of the active metabolite or its analogs to get an effect without serious side effects, such as hypercalcemia and hypercalciuria. However, several large government supported RCTs are ongoing and the results from which are eagerly awaited.
thanks for that- I’m a stoner- so gotta watch how much D i get- as D can lead to more kidney stones-
D is though one of the very few vitamins/minerals/herbs that i have faith in that works- and won’t hesitate to take a megadose IF a cold comes on
Magnesium is another one-