when you put
ecgonine methyl ester
into a search engine a lot of Cocaine articles pop up
I have seen some people talk about taking artemisinin because it has been known to help with malaria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048293/
HOWEVER, if you are in the group that have hemoglobin disorders...here is an interesting blurb (usIng one of the buzzwords by the Italian Dr in a search) . this might apply to people with sickle cell trait, too
There is currently no evidence for clinically relevant artemisinin resistance (Meshnick, 2002), but Kamchonwongpaison and co-workers have reported that P. falciparum parasites in - thalassemic red cells are more resistant to artemisinin and artesunate than parasites in genetically normal cell (Kamchonwongpaison et al., 1994). Because P. falciparum infected thalassemic red cells have a decreased capacity to accumulate drug. In fact, the thalassemics are a group of genetic diseases with defects in globin chain synthesis in -thalassemic, there is decrease in -globin chain whereas in -thalassemia, there is a decrease in -globin synthesis. This result suggests that special precaution should be made for using artemisinin compounds in the treatment of malaria in any area where abnormal globin-gene frequency is high since this will facilitate the development of artemisinin resistance. Paradoxically, thalassemia appears to confer resistance to malaria infection in vitro and in vivo (Weatherall, 1987; Yuthavong and Wilairat, 1993).
This "linking" HCQ mechanism with hemoglobin is kinda thin. Real thin. Ill go deeper into biochemistry journals