Tom Terific
Tom Terific
5 hours ago
Excessive ROS production is indeed part of the inflammatory process. What complicates it is that LOW levels of ROS, from sources such as the mitochondria and NADPH oxidase, are part of normal cellular physiology, serving a signaling role, switching activities of key enzymes on and off by reversible redox reactions. Hydrogen peroxide is heavily involved in such normal signaling. Under normal conditions, the levels of ROS are kept under control by SOD/catalase and the glutathione redox system he mentions here. But if these cellular antioxidant systems’ capacity to maintain ROS at physiological levels is exceeded, then you get oxidant stress. And that can trigger inflammation. Even inflammation plays a normal role in host defense against pathogens, and as an initial step in the the repair process after an injury, and as part of that normal response, there are steps to tamp that inflammation back down once it’s no longer needed. Like excess ROS, it’s when inflammation gets out of control that problems arise. Finally, inflammatory cells themselves, e.g. macrophages, neutrophils, actually do their thing by generating ROS—it’s part of how they attack invading pathogens. Unfortunately, other things can trigger an inflammatory response besides an invading pathogen, and if that inflammatory response becomes dysregulated, diseases can result. Most of the big diseases plaguing Western society these days—cardiovascular disease, cancer, arthritis, inflammatory bowel disease, type 2 diabetes, autoimmune disorders, ischemia-reperfusion injury, etc. all have ROS-associated inflammation at their root. This has been recognized for decades now, and it is a huge area of research interest in biomedicine
b. ho
4 hours ago
In an other video Dr. Seheult states he takes Quercetin + zinc + vit c + vit d + (help me here someone) as a prophylaxis to prevent infection.
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Bernardo Cantu
Bernardo Cantu
4 hours ago
@b. ho and NAC it looks like.