I think you have to consider the blocking scheme as much as the talent of the O line. The Niners ran well using zone blocking, misdirection, play action, a blocking TE and inarguably the best blocking FB in the league. Lamar Jackson accounted for half of the Raven’s rushing yardage using the zone read that Kaepernick made his splash with ten years ago. Houston made it to the playoffs using a power back to take on passing defenses. The good teams can do both and can stop both, power and scheme. IMHO the Niners lost the Super Bowl on the offensive side of the ball. Good offensive teams will score on anybody so have to be able to outscore them not hand your defense a 10 point lead in the 4th quarter and expect them to stop a good offense while you turn conservative on offense. KC played 8-9 Jan in the box the whole fourth quarter knowing SF wanted to run.
If course. The O-line matters, as does the blocking ability of tight ends and backs. But everyone will acknowledge that run blocking is easier for the O-line so you can make due with lesser talent if you emphasize the run. And you can take advantage of linemen pulling since they don't have to hold blocks against pass rushers, gaining an extra blocker at the gap.
IMHO the Niners lost the Super Bowl on the offensive side of the ball.
They inexplicably tried to switch to a passing attack in the 2nd half and it cooked them. Just like forcing a pass rather than running it on the goal line with Marshawn Lynch probably cost the Seahawks a Super Bowl.