Corona Virus Daily Thread #38

[riri]

ETA — Now we 100% definitively know why they conserved nothing. $$$

[a little elbow grease]

That is brilliant and funny.

Thank you for posting.

[LilFarmer]

WA
7,984 cases with 338 fatalities: https://www.doh.wa.gov/Emergencies/Coronavirus
7,984 cases with 343 fatalities: https://coronavirus.jhu.edu/map.html

*****
CA
15,158 cases, 350 fatal
https://coronavirus.jhu.edu/map.html

AL
Confirmed cases: 1842
Hospitalized 240
Died from illness 32
https://www.alabamapublichealth.gov/infectiousdiseases/2019-coronavirus.html

[Black Agnes]

Meant to reply to this yesterday.

That is so stolen! :)

[riri]

That is hilarious.

[Black Agnes]

Just found out a lady we know had it. Thought it was strep for the better part of a week but when the antibiotics didn’t work they tested her.

She slept for 2 weeks straight. As in slept 23.5hrs a day. Had no taste for anything. Drank water, presumably peed, and slept. For 2 weeks.

Said it whupped her ass, and was definitely NOT the flu or strep.

She’s in her mid 30’s.

She’s still in quarantine because she needs a negative test now.

[Myrddin]

One of my classmates is on a ventilator today in San Diego. His band plays at a local night club and most of the class still in the area go for dining and entertainment. The class prayer warriors are praying hard today.

[Black Agnes]

And she’s not overweight and has no other conditions.

Still whupped her ass.

And still has no sense of taste or smell.

[RummyChick]

for the scientists..from a few days ago from a DR (note the parasite example..maybe why that dog drug works)

https://texags.com/forums/84/topics/3104258

Marcus Aurelius1:04p, 4/2/20AG
Witnessing another one. Symptom day 10 sudden huge spike in ferritin, CRP, LFTs and neutrophil/lymphocyte ratio. Chest x-ray ARDS exploding. Max vent, proned. New onset renal failure and shock. Depressing. Nothing to do but watch the inevitable play out. Steroids? Can’t get compassionate IL-6 inhibitors now.

—
When their N/L goes over 20 the survival rate is zero. Seems the lymphocytes are being decimated. I think it’s an important pathophysiology mechanism of this severe disease

---

So we need to block the immune system at the point where it stimulates neutrophils. Reminds me of how parasites preferentially stimulate eosinophils and cause Loeffler’s which I have actually had a case secondary to cutaneous larva migrans.

Since the TNF drugs decrease neutrophils, seems like it is definitely worth a shot. Maybe give the plaquenil cocktail to suppress the virus and use the TNF factors to halt the cytokines storm?

---

No. But our large university hospital that has 52 COVID-19 pts is near capacity. Once that happens we will get deluged. We are 400 beds. I believe the 4/15-4/20 peak theory.

[chris37]

He is very creepy for some reason.

[RummyChick]

NawlinsAg01In reply to Infection_Ag11 • 8:48p, 4/2/20AG
Good. Those were very quick to get going but I hear supplies are limited at each site. A friend in NJ said they received drug to treat 5 patients and they have >100.
REGN has additional studies in the works, as does just about everyone else. This is the most collaboration I’ve seen between agency, investigators, pharma and CRO in my entire career....thank you guys on the front lines.

[chris37]

I literally just got the DU insult.

For a doctor no less.

/facepalm

[Jane Long]

Scary.

I wonder how long before she’ll test negative.

(That Yonkers teacher still tested positive three weeks after diagnosis.)

[Black Agnes]

Good question.

The only thing her husband could get her to eat was a can of (hopefully heated) blackeyed peas.

She wasn’t fat before, she’s probably emaciated runway model skinny now.

[chris37]

From*

[Jane Long]

Eeeeeew....what an evil looking creep.

[RummyChick]

Infection_Ag11 said:
Feel like we brought someone back from the brink with tocilizumab. Gave the patient 400 mg yesterday and another dose 12 hours later, in just 24 hours O2 requirements down from 100% FiO2 to 60% on the vent, down to 1 pressor from 3 and can now tolerate volume removal with CRRT so lungs sound better.

Long way to go but this guy would be our sickest to survive if he does. I’ve very bullish on the IL-6 inhibitors right now based on our experiences and the other anecdotal reports across the world. Hopefully the studies will show benefit because this would open a whole new door for post-viral cytokine release patients.

[RummyChick]

if you need hand sanitizer this is over the 60 percent

https://www.prayerlavendergarden.com/collections/cleansers

[Black Agnes]

https://www.sciencedirect.com/science/article/abs/pii/S1357272596001288

Wonder if supplementing with iodoral/iosol and selenium would do the same thing prophylactically...

[RightGeek]

Harvard Law students want licenses without having to take bar exam - https://www.thecollegefix.com/harvard-law-students-want-licenses-without-having-to-take-bar-exam/