Corona Virus Daily Thread #38

[Mariner]

Yesterday's thread here:

http://freerepublic.com/focus/chat/3831710/posts?page=1

[Jane Long]

I guess this is the beginning of what POTUS/Task Force have been warning as “‘Horrendous’ Coronavirus Deaths in Coming Days”.

[calenel]

“I have come to believe that millions more have been infected by WuHan Flu than credited with it but for maybe 90% it is a little thing that might not be even noticed.”

Nope.

We know the distribution of severities. But even if it were your 90%, where are the other 10% of cases and the bodies to go with them?

The flu still exists. Many people had flu-like symptoms such as you describe, often predating the identification of Patient Zero (myself included). It was likely the flu. Otherwise the hospitals would have been flooded.

Now, if it was some weak strain that somehow got out earlier than the reports, it probably wouldn’t matter, since there is no guarantee that one strain immunizes you against any others. NYC is ample evidence that if such a strain existed (can you imagine it didn’t get to NYC, somehow?) it did not confer immunity.

There is a lot of #WuFluMeToo going around It’s human nature.

[calenel]

“3. Hillary would have been less likely than Trump to implement an early China travel ban.”

Hillary has a Chinese arm so far up her backside she has Panda paw prints on the insides of her eyelids.

This would have been ignored until a convenient scapegoat could be found.

[Mariner]

757 in NYC alone.
In 24hrs.
They are running out of room for the bodies.

[Jane Long]

I wonder where the flubro/deniers are with their vids of the makeshift morgues, now.

:-(

[ETCM]

Those who think they had COVID-19 before community spread was obvious are almost certainly wrong. This is not a virus that hides. When community spread begins, infections and associated hospitalizations ramp up quickly in a pretty predictable manner outside of mitigation efforts. If you are a shut in, and had no opportunity to infect others, and are only talking about a couple weeks ahead of community spread, then there is a very small chance it was wuflu. If you have normal interactions with people, and no one around you became ill, or if your illness was more than a couple weeks ahead of the curve, it was something else.

[datura]

Did you read the genome sequencing article on the virus yesterday in the Slimes?

[Mariner]

pls tell us

[semantic]

I would suggest not bothering with CDC data. They are often days behind, not accurate, nor corrected/updated.

Really, the best site(s) are the respective country/state wiki pages, where OCD autistics drill through arcane detailed gov't reports in a battle for the right to claim 'victory' among their fellow incel peers. Often times you'll see someone going back 2-3 days to edit/adjust a tally by one or two, and then of course roll that effect forward on the associated charts & graphs. That's some mighty fine obsession with detail ...

Secondly, CDC - for obvious reasons - is focusing on the USA. But, since the USA lags a handful of other countries - specifically Italy by 8 days - we can look to them to gain some insight as to infection/hospitalization/mortality patterns. (Note the key here is series aka trends not absolutes. If Italy has been under/over counting, it's ok as long as they've been consistently following that pattern.)

So, when we look to Italy's CV deaths stats and trace them over the last 18 days, what do we find? Surprise, we discover they topped out 9 days ago, and are now approx 43% off that top (525/919). [3/19-4/5/2020]

Just as a you don't have to be a weatherman to know which way the wind is blowing, so too the end game with CV. Some hold outs are displaying classic stages of negotiation - even anger - but soon enough comes depression, then resolution. Anyone taking an over/under on the number of FR handles that are going to be "retired"? LOL

[datura]

The link is here:

https://www.nytimes.com/interactive/2020/04/03/science/coronavirus-genome-bad-news-wrapped-in-protein.html

I’ll post some snippets - lots of info in it.

[bob_esb]

Is this true - that India is shutting exports

https://www.bloomberg.com/news/articles/2020-04-05/india-bans-all-exports-of-trump-s-game-changer-virus-drug?fbclid=IwAR1a2Zf2w1kMPxbx3Dr27ZvqFWSs66w28oSOAaEFDC6a1uG30EajHTPw3E4

[chris37]

Here’s what happened. Oh boy, here goes...

I went over to my buddy’s house, he had just left his wife. He moved in with one of his work buddies, rented a room from him. The guy was sick in the living room, noticeably sick.

My buddy says okay, I’m going to go get ready, go talk with him in there... so, I did. I already knew about CV at the time, and I was not happy with this. I remember thinking in my head at the time, f***!

A couple of days later, I got sick. Started in the throat, proceeded downward. I could feel it at the top of my chest, lasted maybe 3 days, and it never went any further that I know of or could feel. Was taking Sambucol at the time.

About a month later, my buddy says hey you remember when yo got sick from Jimmy (made up name)? I said yeah. He said here’s what happened.

Jimmy said he went to visit a local massage parlor in Pensacola. The ladies there are Chinese. They all had masks on and were sick with something. That’s where Jimmy says he got it.

That’s all I know about it. Jimmy is a former Navy mechanic. Might Jimmy do something like this? Seems possible.

So I don’t know. I would like to take an antibody test. I’d be interested to see those results.

[impimp]

What is your opinion on the worldometer site?

[impimp]

Even if there was only one death they would have a “makeshift morgue” - they are treating the bodies as hazardous waste. It’s just the flu, bro.

[datura]

The genome of the new coronavirus is less than 30,000 “letters” long. (The human genome is over 3 billion.) Scientists have identified genes for as many as 29 proteins, which carry out a range of jobs from making copies of the coronavirus to suppressing the body’s immune responses.

The first viral protein created inside the infected cell is actually a chain of 16 proteins joined together. Two of these proteins act like scissors, snipping the links between the different proteins and freeing them to do their jobs.

Research on other coronaviruses has given scientists a good understanding of what some of the SARS-CoV-2 proteins do. But other proteins are far more mysterious, and some might do nothing at all.

Cellular Saboteur · NSP1

This protein slows down the infected cell’s production of its own proteins. This sabotage forces the cell to make more virus proteins and prevents it from assembling antiviral proteins that could stop the virus.

Mystery Protein · NSP2

Scientists aren’t sure what NSP2 does. The other proteins it attaches to may offer some clues. Two of them help move molecule-filled bubbles called endosomes around the cell.

Untagging and Cutting · NSP3

NSP3 is a large protein that has two important jobs. One is cutting loose other viral proteins so they can do their own tasks. It also alters many of the infected cell’s proteins.

Normally, a healthy cell tags old proteins for destruction. But the coronavirus can remove those tags, changing the balance of proteins and possibly reducing the cell’s ability to fight the virus.

Bubble Maker · NSP4

Combining with other proteins, NSP4 helps build fluid-filled bubbles within infected cells. Inside these bubbles, parts for new copies of the virus are constructed.

Genetic Camouflage · NSP10

Human cells have antiviral proteins that find viral RNA and shred it. This protein works with NSP16 to camouflage the virus’s genes so that they don’t get attacked.

Copy Machine · NSP12

This protein assembles genetic letters into new virus genomes. Researchers have found that the antiviral remdesivir interferes with NSP12 in other coronaviruses, and trials are now underway to see if the drug can treat Covid-19.

As the infected cell reads the RNA sequence for NSP12:

ucagcugaugcacaaucguuuuuaaaca...

Viral Proofreader · NSP14

As NSP12 duplicates the coronavirus genome, it sometimes adds a wrong letter to the new copy. NSP14 cuts out these errors, so that the correct letter can be added instead.

Cleaning Up · NSP15

Researchers suspect that this protein chops up leftover virus RNA as a way to hide from the infected cell’s antiviral defenses.

More Camouflage · NSP16

NSP16 works with NSP10 to help the virus’s genes hide from proteins that chop up viral RNA.

Spike Protein · S

The spike protein is one of four structural proteins — S, E, M and N — that form the outer layer of the coronavirus and protect the RNA inside. Structural proteins also help assemble and release new copies of the virus.

The S proteins form prominent spikes on the surface of the virus by arranging themselves in groups of three. These crownlike spikes give coronaviruses their name.

Part of the spike can extend and attach to a protein called ACE2 (in yellow below), which appears on particular cells in the human airway. The virus can then invade the cell.

The gene for the spike protein in SARS-CoV-2 has an insertion of 12 genetic letters: ccucggcgggca. This mutation may help the spikes bind tightly to human cells — a crucial step in its evolution from a virus that infected bats and other species.

A number of scientific teams are now designing vaccines that could prevent the spikes from attaching to human cells.

Escape Artist · ORF3a

The SARS-CoV-2 genome also encodes a group of so-called “accessory proteins.” They help change the environment inside the infected cell to make it easier for the virus to replicate.

The ORF3a protein pokes a hole in the membrane of an infected cell, making it easier for new viruses to escape. It also triggers inflammation, one of the most dangerous symptoms of Covid-19.

Envelope Protein · E

The envelope protein is a structural protein that helps form the oily bubble of the virus. It may also have jobs to do once the virus is inside the cell. Researchers have found that it latches onto proteins that help turn our own genes on and off. It’s possible that pattern changes when the E protein interferes.

Signal Blocker · ORF6

This accessory protein blocks signals that the infected cell would send out to the immune system. It also blocks some of the cell’s own virus-fighting proteins, the same ones targeted by other viruses such as polio and influenza.

Virus Liberator · ORF7a

When new viruses try to escape a cell, the cell can snare them with proteins called tetherin. Some research suggests that ORF7a cuts down an infected cell’s supply of tetherin, allowing more of the viruses to escape. Researchers have also found that the protein can trigger infected cells to commit suicide — which contributes to the damage Covid-19 causes to the lungs.

End of the Line

The coronavirus genome ends with a snippet of RNA that stops the cell’s protein-making machinery. It then trails away as a repeating sequence of aaaaaaaaaaaaa

This is an excerpt- but most of the article is above to skip the paywall.

[Dr. Sivana]

People who say coronavirus...

What about those who say "Wuhan Flu" or "Kung Flu"?

[SlipperySlope99]

Jimmy's got the COVID-19.

[chris37]

Chris is laughing out loud!

[Jane Long]

Funny how the flubra, who has his own, segregated thread, just cannot resist posting on the CV threads?

There goes the moth to the light correlation, again.

[semantic]

Just another 3rd party site. I wouldn’t be surprised if they’re also running some social media accounts.