Posted on 10/14/2019 10:45:03 AM PDT by BenLurkin
In the 1950s, researchers stumbled upon a new class of drugs that provided relief for those suffering from schizophrenia. These drugs were known as antipsychotics and, as the name suggests, they reduced symptoms like hallucinations and delusions primarily by reducing the levels of dopamine in the brain. This led clinicians and scientists to argue that dopamine was linked to the experiences of psychotic symptoms, and a concerted research effort ensued, seeking to solve the puzzle of why excess dopamine might produce hallucinations.
Although it was later shown that increasing dopamine could produce hallucinations, establishing a consistent link between them, it has not been clear why.
They achieved this by taking advantage of a simple fact: Your brain is lazy. It makes shortcuts to understand the deluge of information that bombards it daily. If youre presented with consistent information, consistently, your brain adjust its expectations of reality in turn. This is the basis of Bayesian theories of how we perceive the world that is, the brain makes inferences about the world around us based on statistics and probabilities on what is likely to occur.
[I]ncreasing dopamine made it more difficult for participants to adjust their perception an effect comparable to how the hallucinators had struggled. Moreover, the extent to which participants struggled was strongly associated with the severity of hallucinations but not with any diagnosis of schizophrenia. In other words, the difficulty appeared to be associated with a symptom, not a diagnosis.
Using brain imaging, the researchers also showed that an increased capacity for dopamine release, from a part of the brain known as the striatum (an area involved in schizophrenia), was associated with the severity of hallucinations. Together, these experiments showed that excess dopamine was associated with difficulty in accurately predicting reality.
(Excerpt) Read more at inverse.com ...
Yes, I recall that. When we were stationed in Germany in the late *mhgys’s* gas was at $1 a litre, and we needed ration cards for it. I still think it was outrageous because at the time, gas was about 35¢ a gallon, Stateside.
Good to see you!
You turned up missing long about the same time as No Cmpromiz went to tell jokes and sing hymns to the Lord, and I’ve missed you both. But yer mum posted some Monkey Face orchids that I fell in love with on FB and that cheered me up!
I saw those Orchids and was going to ping you, but reasoned that it could break your “anonymity “.
They certainly are pretty. No doubt coming to a garden near here next summer. I wish you cold have met her Mum. She could “make a Brick grow”. I’m only good with trees...I use a Stihl... :D
Roofing Examiner sounds ominous.
It actually hasn't rained today , wonders may never cease .
If he says our roof has storm damage, the insurance company will pay for part of the replacement cost. If not, we’ll have to replace it all at our own expense ... although not any time soon, if the examiner says it’s not damaged.
Eek, doesn’t sound to good.
Use your powers on him...a mind meld if necessary.
Surely if it is damaged,it is damaged? Fingers crossed.
The last time I was in Church was last Friday, there was a Bach recital by the Oxford Philharmonic in the University Chapel. Superb acoustics.
Yes, it’s either damaged or not. I hope not. It’s supposed to be good for at least another five years.
Oh I see, nothing blindingly obvious .
Fingers will remain crossed .
Just about to have my last Ale before navigating in the general direction of home. :)
Good to hear from you, Moose.
I thought Britain was going to disappear off the face of the earth when Brexit happened.
Gloomy and drizzly here.
Bored and not sure I can function on a higher level. UNNGH.
My dad could make anything grow, and my older sister has a green thumb. Me? I’m a serial plant killer with a black thumb.
Actually, if you look at my FB home page you’ll see my nickname there! :o])
A Good Afternoon to you, ArGee.
Britain isn’t going anywhere quietly. Who would look after the zero meridian?
The negotiations have entered the belligerent stage, the EU has realised the size of the cash cow that just left the saloon, and has a minor panic on the go. Nice.
How is your world going?
I’ve been watching “Endeavor,” and I love when the choir sings. My poor little sound system doesn’t do it justice, even by a fraction. If only...
Sunwise, same as always. Of course, I guess that's going to be true by definition.
Today I noticed a serious shift in our relationship with our client. They're beginning to trust that these changes we made in January (which put me in charge) will actually help. So that's progress.
Of course, a part of today's meeting is asking what will be impacted if we have to work remotely due to COVID-19. 16,000 have died of the flu this year, but NY is in a panic because a couple of hundred have caught something that's not all that fatal. I guess we have to panic to prove we're alive.
No worries, Kitteh—we have lots of cat food.
Hey, y’all.
We bought more just recently.
Light rain, 57°, breezy.
Chance of GPS zombies
Very large kitten is sneakyin' ur keyboard.
Rain. Rain all night. Lots of rain when I have to drive into St George. Unngh. GPS Zombies will be traversing the freeways, day-dreaming, not paying attention to conditions.
Me, takin’ the back road...Old Highway 91, that used to go from San Diego to the Canadian Border and beyond.
The glass shard is still in my foot. Another round of Prid, and limping, even though I should be staying off my feet for the next few days. *sigh* Should I wait a week until my foot heals. (Heels?) I don’t expect an answer, just axin’ mese’f.
She’s a pretty little cali, sneakyin’ on da keybordz!
Good morning.
My brain is still squeezed together.
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