Well ya got me there, I figured somebody would have hacked them. Or made reproductions. Emulators. I don’t believe I’ve ever played any of those games. Do you suppose they are actually going to play it, or is it going to be displayed on a shelf, and subject to veneration?
Emulators exist, but you can’t play an original cartridge in an emulator - someone has to dump the ROM chips in the cartridge into a file with a specialized reader and the cartridge is destroyed as a result. Sure, you can play it on a PC that way, but part of the nostalgia is playing a game on the original hardware (which in the case of Nintendo stuff has actually weathered time shockingly well).
Reproduction cartridges were briefly a thing... twenty years ago. They’re gone now and they were really bad knockoffs at the time.
It’s probably going to be much like any other collectable - put in a collection and looked at/gather dust. You can get used Kid Icarus cartridges on eBay for far less if you want one to do a ROM dump or to actually play in an NES. As in “Cost is $15” less: https://www.ebay.com/itm/Kid-Icarus-NES-game-cart-authentic/223608336366?hash=item3410186fee:g:nGoAAOSwe~tdQzm8
So, this cartridge in its unopened box is no different than someone putting a 0 mile 57 Bel Air on a plinth, a bottle of Chateau Margaux 1787 red wine in their cellar in a locked case, or Monica’s stained blue dress (last went at auction for $288,050.10) put in a display. The value of the item is its collectability and the value collectors are willing to pay for it, not in the functionality of the object. Indeed, to use it for its function/intended purpose would be to destroy the collectable value.
One possible use for it is for a collector to be assembling a perfect, never used typical Nintendo Entertainment System of the day, complete with all the games (unused if possible) that were available for it at a given point in time - just like earlier collectors did things like assemble an entire Ma Bell switching office room, or a Western Union telegraph office, etc.