With all the anti-vaccination people out there a pandemic of something becomes more and more likely. Smallpox would be horrible.
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Smallpox vaccinations ceased in 1972. It was considered eradicated. However, we know that some countries have kept it in their bio-vaults. It would make a terrific bio terrorist weapon in the wrong hands.
Given the mutations of viruses, with the flu, it is hard to get an effective vaccine. While I did get the pneumonia vaccine, I never get the flu vaccine. I just stay home and avoid crowded places. Try to have good hygiene. Usually works.
I've not heard anything good about the flu vaccine. I'll never get one.