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I presently have three great cats. We travel regularly between homes in Cincinnati Ohio and Naples Florida. (And also to Gothenburg Sweden.)

I drive the cats. Wife and kid sometimes tag along, but usually fly back and forth.

We make the trip back and forth 3-5 times a year. 1150 miles each way.

When I tried to keep them in carriers the whole way, they would go crazy. They would poop all over and get it on themselves, they would scream, chew on the carriers, etc. it was awful.

Now, I just let them roam around loose in the car. I keep a litter box on rear seat floorboards and offer water and snacks at every stop.

They do great now. They just find their own spots in the car and sleep. One cries for a while but will calm down. Another likes getting to passenger floor in a cardboard box. Third goes to rear of station wagon and looks out the back.

I got them used to it by leaving them in garage with car doors open and a litter box in its spot along with snacks and toys. Also many short drives got them used to it.

I had gotten Valium from vet previously but never needed it.