[If you find bed bugs in your house, I suggest burning your house down. Possessions included.]
An acquaintance’s experience was far less involved. Bed bugs need to eat. And the only thing they can digest is blood. If you don’t have pets, the most abundant source of blood is human beings. So he mined all the approaches to the bugs’ food source with bed bug spray (available fairly cheaply by the gallon from Home Depot) for about a month, and sprayed all visible infestations daily over that period. Now, he may get cancer from the bug spray. But at the end of that period, he was bed bug-free. Now, if roach control were that simple, exterminators would go out of business.