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When I first began to look at these attacks, this breed-type of dog, and these pit bull owners and apologists, I was insulted, called names, and told to “educate myself”.

I educated myself. Other people have also done this.

What I have found, at the end of my latest search, is that these dogs have been bred for brain abnormalities.

. . .abnormal disinhibited behavior is not functional, and it is unpredictable. Although high arousal and sudden attack can be functional in certain environments, this behavior is pathological in a safer environment, where a high level of arousal and aggressiveness are not necessary and only lead to unnecessary attacks and injuries. Research implicates the frontal cortex, subcortical structures, and lowered activity of the serotonergic system in impulsive aggression in both dogs and humans. Impulsive aggressive behavior in dogs seems to have a different biological basis than appropriate aggressive behavior.

Kathelijne Peremans, DVM discovered this by studying two different populations of impulsively aggressive dogs. Each dog had executed one or more attacks without the classical preceding warnings, and the severity of the attacks was out of all proportion to environmental stimuli. Peremans found a significant difference in the frontal and temporal cortices of these dogs, but not in the subcortical areas, compared to normal dogs. Peremans also found significant dysfunctions of the serotonergic systems among these dogs.

(Excerpt from book: The science of how behavior is inherited in aggressive dogs)(Semyonova)