[smileyface]

half-life rapid, in rat study abstract I saw...interesting...

“In 1954, Hoffer et al. reported that adrenochrome, an oxidative metabolite of epinephrine, was psychotomimetic in humans when administered intravenously (Hoffer et al., 1954). This and other observations led the authors to hypothesize that adrenochrome is overproduced and responsible for some symptoms in schizophrenia (see review by Mills, 2010). Hoffer et al. further proposed that vitamin B3 (niacin) might be therapeutic for schizophrenia since it may act as a methyl acceptor to decrease the conversion of norepinephrine to epinephrine, thus inhibiting adrenochrome synthesis.”

Old research, no abstract/article online...
THE ADRENOCHROME THEORY OF SCHIZOPHRENIA: A REVIEW.
HOFFER A.
Dis Nerv Syst. 1964 Mar;25:173-8. Review. No abstract available.
PMID: 14130059

[reformedliberal]

Interesting. Will add to the database.

[grey_whiskers]

Thanks.