Can I conclude from this that adrenochrome, as a metabolite, is mostly excreted and likely fast enough that any effects would be short-lived?
I think the shock value of the adrenochrome meme makes it a candidate for click bait. I’ve felt for a while that it’s a big troll.
Also, looks like it would have to be infused to have any sort of effect outside of a brief jolt. Ingestion would subject it to stomach acids and I doubt there’s any real effect from that.
I do always ask:”By what mechanism?” Adrenochrome just doesn’t seem to be a candidate for abuse or addiction. I have seen articles touting actual treatments of infused teen blood for rejuvenation. No idea of quantity or frequency, but I’ve seen $8k/per infusion. I’m sure there’s a lot of different elements involved in blood besides adrenaline. Maybe even just the effects of highly-oxygenated red blood cells. Maybe that’s the mechanism, which explains the effects attributed to hyperbaric treatments.
I have a suspicion deep down that these people consume babies for their stem cells as a way to maintain youth, or some semblance of it. I think this is something that could never be studied ethically, so we don’t know if it is effective, but the long standing folk tales of babies stolen and eaten makes me wonder. The Nazis and the Soviets may have studied it, they had no ethical qualms or IRBs to deal with,\.
What makes you think that a gout of adrenaline from
fear does not secondarily induce a volley of other
materials, metabolites, autocoids, etc. etc.?
half-life rapid, in rat study abstract I saw...interesting...
“In 1954, Hoffer et al. reported that adrenochrome, an oxidative metabolite of epinephrine, was psychotomimetic in humans when administered intravenously (Hoffer et al., 1954). This and other observations led the authors to hypothesize that adrenochrome is overproduced and responsible for some symptoms in schizophrenia (see review by Mills, 2010). Hoffer et al. further proposed that vitamin B3 (niacin) might be therapeutic for schizophrenia since it may act as a methyl acceptor to decrease the conversion of norepinephrine to epinephrine, thus inhibiting adrenochrome synthesis.”
Old research, no abstract/article online...
THE ADRENOCHROME THEORY OF SCHIZOPHRENIA: A REVIEW.
HOFFER A.
Dis Nerv Syst. 1964 Mar;25:173-8. Review. No abstract available.
PMID: 14130059