There are utilities within Windows that can reduce the number of unneeded files (e.g. Accessories -> System Tools -> Disk Cleanup), and third-party utilities that can do even more.
I won't offer specific advice on what files to delete on someone else's system. Ya never know what lurks.
Do a full backup before running any such programs. And run a "verify" pass on it. If you're like me, do two full backups, in case the first one has problems down the line.
http://www.thewindowsclub.com/can-i-delete-delivery-optimization-files-shown-by-disk-cleanup
If so, it does sound like you can delete them -IF- you have disabled Delivery Optimization (that link has details).
Do watch out for the ads on that page. Google has a number of other hits that might work better for you.
Thanks!!