It goes back further. First he pulled out of Iraq before they were able to defend themselves, then he supported the “Arab spring” which destabilized the Mid East. Then he supported the overthrow of Gadaffi in Libya and then he smuggled arms to the Syrian rebels who gave them to Islamic extremists in Syria.
Hillary’s laughing “I came, I saw, he died” comment about the brutal killing of Gaddafi in Libya, paired with a few disturbing photos of same would highlight her attitude and actions as SoS better than anything I can think of.