We drove through that area not too long ago. At that time there was construction with minor delays. My wife wondered outloud what do they do if the road gets cut off. Apparently a very realistic concern. What an amazing, scenic part of the country if you can make it out there though - magnificent!
Best bet between October and May is to travel I-80 or I-40. If traveling to Grand Junction, take US 50 from I-25. Even when there’s no weather you can get mudslides, rockslides, lingering snow, and road-crippling accidents due to blowing winds, icy conditions, and heavy ski traffic.