Apollo 10...holds the record for the highest speed attained by a manned vehicle with 11.08 km/s (24,791mph)
Lots of work to be done to make 22ly in 200 years.
It’s only been 112 years since we got a heavier than air craft off the ground and about 50 since pretty much everyone had to use a slide rule to figure mathy stuff out. I’m betting it’ll come a lot sooner than 200 years.