Long ago I was on a college pistol team, shooting .22 caliber Hi Standard Citations. The real expert shooters could hit a coin-sized target at 50’ all day long. They could probably make head and face shots faster than most shooters could hit center mass with a centerfire. But it does take practice.
I agree. I practice at ranges much less than 50’, but I am pretty good, even with no-sighting quick reaction. Practice.