My .357 big game load is 16-17 gr of IMR 4227 with 158gr hornady XTP. It is right around 1100 fps 4” Bbl smith model 17. I’ve used it for coup de gras on whitetails. Never for takedown. A little too big for hominids. Better with the 125 gr which you speak.
Have taken a small whitetail with my Dan Wesson with the 8’ barrel with a very similar load. It really is a hand cannon and very accurate (all the rage at silhouette shooting in the 70’s), but recently I shrunk it down with the snubby barrel and tiny concealed carry grips and it rides comfortably all day long.
I like the safeties on my revolver much better than the ones on my semi-autos.
“4” Bbl smith model 17”{
17? Typo? Did you mean a model 27?