No one has more faith in the power of the human mind than I do. However, I do not believe that someday we'll overcome the First Law of Thermodynamics if we "just try hard enough." [Nor we will overcome the Second Law of Thermodynamics, the Uncertainty Principle, the Exclusion Principle, ... ]
These are laws of physics, not engineering challenges. The four dimensional space-time we live in has a certain geometry. Trying to overcome that geometry -- which is known in physics as Lorentz Invariance is a waste of time, every bit as much as trying to violate the law of the conservation of energy. The basic laws governing Gauge Bosons [and their classical analogues, like Maxwell's Equations] simply do not work unless the universe is Lorentz Invariant. It's not a matter of being clever or trying hard.
Who really knows what the future holds, we might discover a new law or way that could make some of what we understand either wrong or amended. It is not the end all or be all. I mean what we know today, to someone in the future, we might be seen the same as we see people who still believe in the Platonic Universe where the sun, stars, planets and so on go around the Earth and that there are only 4 elements, Earth, Wind, Fire and Water. Perhaps there is more to it than just adding a few extra “D” cells to the Warp Drive and a RAM upgrade to the hyperspace computer, but you never say never and have to keep the mind open to other possibilities.
Then we know all there is to know about our four dimensional space-time we live in, right?
There is nothing left to figure out, right?
We know everything about that geometry, right?
There are no unexplained anomalies in that geometry, right?