So yes, it is annoying, but the babies can't help it, and their parents can't do a thing about it. Toddlers are a completely different story; if they're screaming and being obnoxious, the parent's CAN do something about that. Usually it involves talking a lot about what the plane is doing, pointing out the window, if you can see anything, or just doing a mighty job of distraction.
I like the idea of them being in the back of the plane, because they usually take the longest with getting settled in their seats, and not having to wait for them trying to do that in the middle of the plane makes complete sense. The same in reverse; folks aren't delayed getting off with parents having to re-load all the kids' gear.
Planes should load from the back, window seats first.
Simple fix to a baby ear pressure: Valsalva Maneuver. You do it every time you hold your nose and blow to release pressure in your ears. A quick hold and release of an infant’s/child’s nose can clear their pressure jsut as well. It might take several tries to coordinate their blowing out and you holding their nose for them, but it works just the same. For children that can safely chew gum, gun chewing can also help.