If your Mac is the only thing accessing the internet, no. If you have your Windows install accessing the internet, it's sandboxed and you do have to run it as a Windows install... with all the protections you would use as though it were a stand-alone Windows. However, if you are using a virtualized HD file, with a backup, it's trivial to throw out the compromised virtual HD and replace it with a copy of your clean backup and go on your merry way in the matter of seconds.
Thanks, now if I can just remember NOT TO ACCESS the internet when in the windows mode.