I always pictured migrating bands of tribes back then in America not a big city. There were a few migrating bands of tribes but they were the minority. The majority were farmers who did some hunting.
There were several cities in North America but it was mostly large villages on the East Coast.
Lacking large domestic animals for protein large cities were mostly not practical.
The Mound Builders had a sophisticated civilization including ceramics and other high artwork. The very earliest European explorers brought diseases that largely wiped out most of the Indians long before settlers arrived. Even the accounts from Plymouth Rock talk about the Pilgrims raiding the food stores of empty Indian villages that had recently been depopulated by European disease.
So most settlers did only encounter roving bands of Indians.