[GoLightly]

Jaguar? Farther south you’d have alpacas & llamas, but I think they would have been more like wool shipments than pelts.

I think of Central & South America, sure they weren’t shipping feathers more than fur? They had a habit of shipping exotic animals willy nilly.

[blam]

A couple hundred years later, these folks died in the millions too.

Historical Review: Megadrought And Megadeath In 16th Century Mexico (Hemorrhagic Fever)

The epidemic of cocoliztli from 1545 to 1548 killed an estimated 5 million to 15 million people, or up to 80% of the native population of Mexico (Figure 1). In absolute and relative terms the 1545 epidemic was one of the worst demographic catastrophes in human history, approaching even the Black Death of bubonic plague, which killed approximately 25 million in western Europe from 1347 to 1351 or about 50% of the regional population.

The cocoliztli epidemic from 1576 to 1578 cocoliztli epidemic killed an additional 2 to 2.5 million people, or about 50% of the remaining native population.

[RightWhale]

It’s possible.