Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
bkmk
Bookmarking also.
The author does not know what he is talking about when he says:
“ACE2 aka GPR109A expression”
They are not the same thing, in any form, if “aka” means “also known as.”
Moar documentation:
Dr Kats NIATONIN— Podcast and Transcript (early draft of the protocol - it has changed a bit plus language warning)
https://otter.ai/u/-Wx6-rY8F9tFqiaYtLfNuP4vBG4?fbclid=IwAR2UyZaywMx6TUmusG-CziIf86e1TDQKULZ8wfJKZ2z4lVULmBUtikn9J6A
Metal chelating and hydrogen peroxide scavenging effects of melatonin
https://pubmed.ncbi.nlm.nih.gov/12662350/
Melatonin mitigates cadmium phytotoxicity through modulation of phytochelatins biosynthesis, vacuolar sequestration, and antioxidant potential in Solanum lycopersicum L
https://www.frontiersin.org/articles/10.3389/fpls.2015.00601/full
Melatonin prevents oxidative stress resulting from iron and erythropoietin administration
https://pubmed.ncbi.nlm.nih.gov/11273875/
Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells
https://pubmed.ncbi.nlm.nih.gov/27614220/
Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
https://pubmed.ncbi.nlm.nih.gov/19781706/
Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization
https://www.nature.com/articles/srep42279?fbclid=IwAR2oV8auLcaByyASFzNwf3P40qgiF31OWEQwqiPd1Ywgnwtosaf3ZrlTSWw
Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells
https://www.jlr.org/article/S0022-2275(20)39224-5/fulltext
Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
-Essentially, according to the ACTUAL health science, prion disease / neurodegeneration = accumulative lack of niacin (and melatonin) over the life course... and so can be prevented—as well as even reversed—simply by repleting niatonin.
https://pubmed.ncbi.nlm.nih.gov/25678560/
ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders
https://portlandpress.com/clinsci/article-abstract/135/3/535/227747/ACE2-and-energy-metabolism-the-connection-between?redirectedFrom=fulltext
IMPORTANT —> Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201801951R
Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-021-00915-3
ACE2 and gut amino acid transport.
https://www.unboundmedicine.com/medline/citation/33140827/ACE2_and_gut_amino_acid_transport?fbclid=IwAR2jDQTmbW_QWnJyVFT_AC-LXqA0WI2I-i-W3yQ4RJ39yR0l8lH5ExCxAno
Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms
https://pubmed.ncbi.nlm.nih.gov/25038318/
Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization
https://www.nature.com/articles/srep42279
Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis
https://www.frontiersin.org/articles/10.3389/fimmu.2021.606384/full
The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
https://www.nature.com/articles/ncomms4944
NAC Bonus materials
N-acetylcysteine as a potential treatment for COVID-19
https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0074
N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation
https://chemrxiv.org/engage/chemrxiv/article-details/60c753ec4c89190f3bad43ca
N-Acetylcysteine Reverses Anxiety and Oxidative Damage Induced by Unpredictable Chronic Stress in Zebrafish
https://pubmed.ncbi.nlm.nih.gov/29876880/
Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease
https://academic.oup.com/hmg/article/30/7/536/6153421
That’s why I put in the notes. Remember, English is not his first language. He means they do the same thing.
Bkmk
Man this is for lay people and English isn’t his first language. That’s why I put replicate in parenthesis. And no one said the store of energy is melatonin.
The point is the virus is using the energy from inflammation. If you can give a better layman’s explanation, please do.
Melatonin starts causing problems at 30 mg. I'm not against going far beyond that, but heck, show a study ever done in the world on 150 mg a day. If you can't, you are the first study participant.
https://www.healthline.com/health/melatonin-overdose
For niacin, the maximum given is 2,000 mg of the sustained release form, but your doctor says to take 6,000 mg a day of the fast flush form. If you can find something that shows 6,000 mg a day of the fast flush form, please present it. If you can't, you are the first study participant.
Look, I have even taken 6,000 mg a day of iodine, which is far beyond the official Upper Tolerable Limit. You have to take selenium and a few other supporting minerals to not cause a problem in your body, but a few studies have actually used this much, and I can point to them.
Don't throw out crazy stuff and encourage people to do stuff no study has ever shown doesn't hurt people. Please.
This is a totally new protocol. The point is it’s working swimmingly for thousands of people. If you don’t want to try it, don’t. You aren’t going to find your desired double blind studies yet. They don’t exist.
PS I’ve done 300mg of melatonin today with 3000mg of niacin. My biggest takeaway so far is a huge reduction in my smokers cough, less desire to smoke, and a decrease in my ravenous appetite. Some old hip inflammation has vanished. My eyelashes are back to normal since they were reduced after cataract surgery (both eyes). I’m sleeping better than I have in a long time.
You are welcome to wait for a double blind study. For the rest of us not mired in dogma, we’ll be fine. Do try to listen to the interview or at least read the transcript.
-Essentially, according to the ACTUAL health science, prion disease / neurodegeneration = accumulative lack of niacin (and melatonin) over the life course... and so can be prevented—as well as even reversed—simply by repleting niatonin.
That study absolutely DOES NOT SPEAK TO MELATONIN—only niacin. You are lying when you say melatonin is part of it, at all.
I’m NOT TALKING ABOUT STUDIES FOR YOUR STUPID PROTOCOL. I AM TALKING ABOUT ANY STUDY, in the HISTORY OF MANKIND, that EVER USED THESE AMOUNTS OF NIACIN OR MELATONIN.
STOP STATING FALSE ARGUMENTS.
But people beyond the trees are hostile enough, with a bunch of skeptics trying to find any excuse to push the jabs instead of anything else.
So having stuff in bad English, makes it too easy for naysayers to jump in and critique.
I think the translation from scientific techie speak to laypersons, on TOP of translating from a foreign language, is what's doing it -- "doubling" might be "well, cell reproduction is when a cell divides in two, so call it 'doubling' "...that kind of thing.
Be nice to have some friendly biochemists/MDs make their own try, at translating & explaining this.
No one ever said it did. I KNOW that varying melatonin dose with niacin intake works for controlling flush. I’ve experienced it and experimented with it and have testimonials from thousands of other people that have done it. You can’t handle anything new. Go back to your white coat dogma and the rest of us will progress naturally and without pharmaceuticals. Good day.
Maybe someone should do a study with these amounts. Did that not occur to you?
I have already stated to you that you are the experiment, when it's never been done before.
Thanks GW. This is a very complicated physiological scenario. I’m doing my level best to explain it in layman’s terms. I’m a physicist, not an epidemiologist. I’m listening to an epidemiologist and applying my skills to do the research (like having to look up words whose root I am ignorant of). Dogma is what got us into this mess, and I intend to have no part of it. If you don’t wish to try it, don’t. They can take their vaccine and be dead in three years.
Kinda like folks being the experiment with the various mRNA vaccines, right? I, and many others, are having quite positive outcomes and having a ball doing it while simultaneously crowd sourcing help for others do it. This is a real world experiment sans the tight laboratory controls the white coats so deeply desire. It's dirty, organic and real which makes it fun.
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