Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
The pain from arthritis is inflammation. Yes, it will help. My anecdotal testimony is that my smokers cough has been reduced by half and dropping every day. Yes I'm a nerd and count how many times I unconsciously cough throughout the day.
WTH!?
Do ya think you could just give us a couple of sentences in explanation? I’m retired but I don’t have time to sort thru this stuff....
Yes, the first flow I made didn’t have the first dose in it. It certainly complicated it, but this is as simple as I can make it.
The first three paragraphs is as simple as I can explain it. In a nutshell NIATONIN pushes out inflammation. Inflammation is what attracts viruses. They use it as energy to replicate. Less inflammation = less viral replication.
I’ve been doing and studying supplement for 50+ years. I’ve always thought that the “flush” was good...that it meant your blood vessels were dilating, thus keeping them elastic.
bkmk
If you are not having pleasant dreams you need more vitamin D.
Take 10 times the RDA on the bottle for a week.
TAKE MAGNESIUM TOO or you may get leg cramps.
The IDEAL mix of those two is that if you don’t immediately need to run to the bathroom when taking the magnesium, you have enough Vitamin D. If you have cramps you don’t have enough magnesium.
After a few days you’ll feel great and poop like a champion.
I would love to hear a clinical explanation of this by this guy!!! I just know what works, from decades of testing and observing. (I am a scientist, after all)
Topical magnesium chloride will get more mag into you and no worries about the bathroom.
I’d love to hear your take on VitaminD and Magnesium- Do they work together in a similar fashion?
Great work- thank you
be back bump THE DR KATS LAYMAN’S VERSION
What confused me at first was the meaning of “flush” in this context. My first thought was it meant an act of purging, as with a toilet. Instead, it’s a specific reaction to taking these supplements.
Correct?
Correct. If you do not have enough melatonin to use up the niacin, it makes it to surface capillaries. It feels like a rash or sunburn. The first intense flush I got was like my hair was on fire.
I’ve always looked at Mg as a mitochondrial fuel for healing purposes. I don’t necessarily think it attacks inflammation directly. As for Vit-D, I see it as a mechanism by which nutrients are absorbed (including Mg and Ca). If the Mg is applied topically, I don’t think Vit-D is necessary for that absorption as it does not go through the liver.
Click the skip link to jump over my long post regarding my objections to some of the Niatonin content linked.
I just started checking into Niatonin theory, as posted. One of the early posts I found was this one:
So I checked out Part 1.
I take issue with Part 1. (more about that in a moment). Further, I take issue with the article posted immediately below Part 1 by the same author.
Covid-19 Vaccines Save Lives. This is not a contentious fact | by Gideon M-K; Health Nerd | Medium
First, he makes the 'causation vs correlation' argument common to our Branch Covidians to disprove concerns over Covid vaccines. He starts by acknowledging VAERS is supposed to be a signal, and in my opinion then goes on to dismiss the signal function entirely.
He seems to double-down, repeating a Covidian talking point:
"This has previously led to things like car accidents being recorded in these systems..."
The CDC gives itself 4 to 6 weeks to vett any new report submitted to VAERS. You can't upload directly (bypass) the CDC. I have spent many hours looking at VAERS resports (specific patient records) and never found any extraneous reports that didn't belong there.
Key isues with VAERS data (withholding large numbers of records, thousands of reports of death following Covid 'vaccination' compared with all other vaccines in VAERS 30 year history) are never mentioned. It doesn't matter whether you argue causation or not (as he does), the 'causation vs correlation' issue existed in prior years as well, so NOTHING explains the extremely disproportionate amounts of adverse events reported post Covid 'vaccination'.
There's JUST SO MUCH evidence of vaccine harm and this author sees ZERO reason concern and endorses Covid vaccines without reservation, before moving on to attack Ivermectin's reputation as fraudulent.
From the Covid article he wrote, "The bottom line here is quite simple — regardless of how you calculate it, if you use the correct figures Covid-19 vaccines are tremendously life-saving. This is not particularly surprising, because vaccines are generally one of the best interventions out there when it comes to cost-benefit as they tend to be so low risk."
So this supposed statistician promotes both the false perception of the 'death toll' of Covid illness and vaunted safety of the Covid 'vaccines'. That's a two-fer.
In my opinion author seizes on nits to pick (e.g., how valid is VAERS ) and denies the existance of anything that contradicts his position. This means he is ignoring the obvious problems and all the experts (Dr. Malone, Dr. Yeadon, Dr. McCullough, Dr. Mikovits, Dr. Tenpenny etc. etc. etc.) and all the other inputs.
He has selected portions of the covid 'vaccine' debate he feels are most vulnerable to criticism, just like our trolls do, and 'sets the table' (what will, and will not form the basis of legitimate opinon) in such a way that far more overwhelming data sources are ignored.
Quoting him, "So it might surprise you that I got a first dose of the Astrazeneca vaccine in April, and I’m getting my second dose today. Ultimately, my nerves are trumped by my knowledge that catching Covid-19 is much more harmful than any of the vaccines that we’ve developed so far."
NO SALE!
In my opinion, this appears to be blatant trolling. Not a good sign for someone putting forth the argument that 1) Ivermectin treatments for Covid is based on fraud and 2) Niatonin is better.
So, back to Part 1 re Niatonin and its implications for use of Ivermectin in the treatment of Covid.
Overall, the author, Gideon M-K; Health Nerd, does the same injustice to the Ivermetcin issue that he does with the vaccine issue. He 'sets the table' to include/exclude information, this time with a flawed Ivermectin study, and pulls it apart, all the while implying he's addressing the central consideration re the use of Ivermetcin in Covid.
In my opinion, the author pretends the true considerations supporting the use of Ivermectin do not exist. There could be 10 flawed studies he could discuss, but what about all the survival? All the hundreds of other studies, even the Nobel prize and the reputations of those who support its use are of more value than the study he makes the centerpiece of his analysis.
The title he gives his analysis is inflammatory (no pun) at a time when citizens all over the world are denied access to appropriate medical treatment.
I reject Part 1 of his analysis, and his Covid vaccine promotion completely. I will look through parts 2 and 3, but I am no longer optimistic because there is something, I believe, intentional behind his opinions that does not bode well.
A research analysis that 'sets the table' with only the weakest data points and excludes all else, while exhorting the safety of Covid vaccines is, in my opinion, at the very least, unethical.
WELP. I goofed. The skip link only works on the other thread. Sorry - I had hoped to save people time and scroll wheels. :(
He also mentions magnesium (as magnesium glycinate) and zinc.
Any thoughts?
Get someone to translate this into English.
Presumed bull pockey based on gobbledegook.
Example:
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin.
Viruses don’t “double” in cells. And the store of cellular energy is ATP, not melatonin.
If you aren't dreaming at all, take B6. BUT take it at breakfast or lunch. For most people, taking B6 just before going to bed will result in vivid nightmares. If taking B6 doesn't result in dreaming, it means you are deficient in Magnesium.
The first time I took niacin, my whole upper body turned blood red. My wife thought I should go to a hospital, but I felt great.
Technically, they are manufactured there, then burst out via lysis, or sometimes emitted:
https://www.embibe.com/exams/multiplication-of-viruses/#Replication_of_Viruses
That was an early take when he had an "Ah ha" moment. There were other things in that protocol like NAC. Although still recommended, only the NIATONIN is necessary.
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