Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Add more melatonin
Sounds like a great thing to slip into the punch at a party!
You'd know. Niacin is sour and NAC is worse.
You missed announcing a couple new protocal and name changes: Alana, and now Alaiacin. I’m only 14,549 posts behind on the chat, though, so I have no idea what’s up with that.
I’m lost and just got a bag of serine. I’mma go with that.
PS I am no longer an admin in the Telegram channel.
numberonepal: You'd know. Niacin is sour and NAC is worse.
#1, I think Mr. K was talking about L-Serine.
If my experience generalizes to other people, it could be a very mellow party. I haven't replicated the laughing incident, but I still feel pretty happy under the influence of L-Serine.
Dr. Kats has joined a network marketing organization (ASEA) that sells nutraceutical products consistent with his niacin approach. I think ASEA’s products cover all the “co-factors” that used to be listed with Niatonin.
The basic protocol no longer includes L-Serine (sigh), which has been replaced by R-alpha-lipoic acid (R-ALA) and selenium.
Dr. Kats means for this to be twice a day, after a meal.
PureBulk is sold out of L-Serine. I was interested to see that they sell a 25 kg (!) bucket of L-Serine — but they’re sold out of that, too. There must be some real addicts out there.
They still have alpha lipoic acid (R-ALA), but they’re out or running low on some forms of it.
I think Dr. Kats actually recommends holding back on zinc supplements because the components of the niacin concoction do such a good job of improving zinc bioavailability. It was only recently that Kats added selenium to the mix.
Although I’m still enjoying my L-Serine, Dr. Kats has now switched to glutamic acid as the main counterpart to niacin, with ASEA supplements and selenium in the mix.
Soon after taking L-Serine the other day, I had another spontaneous outbreak of laughter (while hosting a Zoom call, no less). People said afterward that the weekly Zoom call was a lot more fun than usual — they enjoyed their contact high.
My brother takes his L-Serine and niacin before bedtime, to separate it from his morning blood thinner. He reports that after a decades-long dream drought, he has started to dream again.
Before I even had my first chance to use glutamic acid, Dmitry has switched to resveratrol, which he now thinks is the real deal. To start he recommends gram-for-gram, so if you take a gram of niacin, take a gram of resveratrol. Maybe reduce resveratrol as time goes on.
Sadly, resveratrol is one of the most expensive of the supplements Dmitry has recommended. PureBulk has 100 g for $79.99 ($72 with DMITRYKATS code).
Dmitry spoke (civilly) for four hours last night about the new protocol. He made it sound like his reaction to N + Resv was even better than mine was to N + L-Serine. PureBulk has my order.
If I’d thought to order on Amazon, it might have gotten here in time for Mardi Gras 🎭 🎷 🪗 🥃 🍹
Of course as soon as I got my resveratrol, Dmitry removed it from the protocol. It seems that resveratrol has some concerning side-effects, including pretending to be estrogen. One woman actually had “spotting” after her very first 1-gram dose of resveratrol.
Resveratrol also acts as a blood thinner, so you’re not supposed to use it for two weeks before surgery.
The result of Dmitry’s back-to-the-drawing-board moment is that the protocol is now focused on niacin, R-ALA, and melatonin. Despite Dmitry’s belief that niacin is best 10 mins after meals and R-ALA is best on an empty stomach, he suggests taking them both together, 30-60 min after a meal, once or twice a day. As for melatonin, he recommends taking melatonin once a day, preferably early in day (so with your first niacin dose if you do two), and he recommends taking it in a capsule to make sure more of it gets to your gut.
All of the above is for the healing phase. Dmitry says his maintenance regimen is 1 g niacin, 400 mg R-ALA, and 6 mg melatonin once every 2-3 days, with additional or higher doses if he goes into a situation where he might be exposed to a virus.
HOM3OSTASIS combines immediate release nicotinic acid (flush NIACIN) + α-LIPOIC ACID (just ‘R’ version is best), as well as Melatonin (as soon as it is comfortable to supplement), along with sufficiency of the other B vitamins (namely pantethine, thiamine, & riboflavin)DOSING (adults):
For therapy, R-ALA (R-alpha-lipoic acid) in relation to Niacin can be in a 1:2 mass ratio of R-ALA:Niacin (e.g. 0.6 g R-ALA + 1.2 g Niacin) to 1:1.5 mass ratio of R-ALA:Niacin (e.g. 0.6 g R-ALA + 0.9 g Niacin), both taken together… Upon feeling better & especially for health maintenance, naturally we will be lowering R-ALA dose on average from the usually higher levels for therapy, and so ratio can then cross 1:>2
If new to niacin, start each dose anywhere from 50 mg up to 500 mg. You MUST experience the flush, which is literally clots being killed, and NOT what is actually acutely bothersome about niacin. Undesirable reactions are simply the excess amount (could even be the majority at first) of niacin (an acidic molecule) moving through vasodilated capillaries (whilst temporarily acidifying exterior blood + tissue cells as it clears) that doesn’t get into cells, until lipoic acid restores cells’ ability to allow niacin in more as you build up (expeditiously but comfortably).
Flush (tingly, inverted sunburn-like feeling w/o pain; body turns red; starts in 10-15 min, peaks 20 min in, cools down thereafter; can last 45 min, unless body is sensitive - add more lipoic acid next dose) is literally clot-killing but still only preliminary mechanism of niacin. The flush (& any undesired acute reactions) will gradually (over next four consecutive doses or so) calm down & completely go away if dosing is continued at least 1x a day (preferably twice to start) as dose continues to be raised towards a 1 g dose (some won’t even need this high ever, while many—less metabolically intact—will benefit growingly with up to 2 g per dose, and a minority enjoy up to even 4 g per dose - don’t do this high unless emergency or comfortable w/ niacin & want to expedite therapy w/ higher dose once it’s getting into cells appropriately). Once flushing doesn’t occur after subsequent sufficient-level dosing, clotting/thrombotic environments (i.e., foundation of inflammation on the surface phospholipid membranes of cells from which it aggregates & accumulates forward) have been cleared (at least in those cells that are at the time able to allow niacin in sufficiently) & will remain at-bay (further anti-inflammatory, antipathogenic, & immune-modulatory pathways/actions of niacin then assume, assuming lipoic acid administration is continuing to promote niacin into cells more)… If you temporarily stop niacin, once restarted, that dose will induce flush response again (never as intense as first time, primarily due to novelty of experience & finally real medicine), meaning micro-clots / new inflammation layers have regathered on cells’ surface membranes since last dose. Here, sufficiently supplementing niacin to overcome & then no longer flush forward, is premier anti-clotting counter. WE WANT MORE THAN ANTI-CLOTTING THOUGH!
To fully enable niacin, we have lipoic acid.
For SERIOUS recovery, may need to reach 1-2 daily doses as high as 600 to 800 mg R-ALA (so anywhere from 900 to 1,600 mg Niacin) per dose; best to build R-ALA + Niacin together at around above-mentioned^ ratio, raising R-ALA as anchor if things aren’t clicking (assuming niacin is near 1 g / enough). Adults for therapy: if one dose for the day, then start around 400 mg R-ALA (some adults may need & experience expedited benefit starting with even higher dose up to 600 mg, usually also as they build niacin up to needed levels (assuming if around / at least 1 g niacin dose); again, note some may not need to get to these levels, so build up at a sufficient but comfortable pace… if dosing 2x daily for therapy: starting at 250 mg but maybe needing to reach 300-400 mg R-ALA per dose (if recovery not clicking after a few days, evaluate raising R-ALA dose, assuming niacin is sufficient with it)
He had radiotherapy for head-and-neck cancer in the early 2000's and had developed a "permanent" bald spot due the radiotherapy. Since he's been doing niacin his bald spot grew back in.
He's also enjoying the L-Serine, as I probably mentioned before. Although I take mine in the morning (with the awesome side-effect of increased happiness), he takes his in the evening. After decades of minimal dreaming he now dreams constantly in Technicolor, with many of his dreams bringing back long-lost childhood memories.
Probably too late for you to see this in time, but Dmitry is doing another video chat this afternoon at 3 pm Eastern time on the Hom3ostasis (formerly Niatonin) Telegram channel.
I’m still trying to get rid of L-serine.
What do you mean? What’s wrong with L-serine?
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