Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Waow! That sounds kinda spendy.
Well, that was fun! I haven't had the niacin yet, but I took 12 grams of serine and then started breakfast. During breakfast -- pancakes, eggs, bacon, sausage, thanks to Mrs. AZLiberty -- I broke out in uncontrollable happiness and laughter.
I've never heard anyone advertise side-effects like this on TV.
Each capsule is 2 g, so it was “only” 6 capsules. 180 capsules cost $19.95, so it’s about $0.11/capsule, or $0.66 for my morning hit. Well worth it!
Dmitry recommends a minimum of 12 g as a starting dose of L-serine for older folks (I qualify), and possibly ramping down as time goes on. The maximum recommended dose is 25 g.
Still chuckling ... Is this stuff legal?
The instructions on the L-serine bottle say to avoid operating heavy equipment after use. I understand why.
Another way to get your niacin: https://www.cloud9boston.com/programs
(just appeared on Seriacin Telegram).
Boy, did I mess up. I should have known that those capsules couldn’t hold 2 g each. The bottle said that a single serving was 2 g, but if I had had my reading glasses on I would have noticed that a single serving was 4 capsules. I took 6 capsules so, instead of 12 g, I actually only took 3 g.
Number One, you were right about the cost. 12 g would be 24 capsules, or more than $2.50 a dose. Still worth it!
Now I’m a little worried about jumping up to 12 g. If 3 g made me happy to the point of laughing uncontrollably, what is a 12 g dose going to do? We shall see.
I think the uncontrollable laughter is all in your head, AZ! ;-)
I’m just looking for relief from my winter seasonal allergies (for lack of a better term) that are here with a vengeance with the change of weather. So much mucus, and all in *my* head, quite literally, unfortunately... none of the supplements I take do jack for that, and a few herbs help some, but only temporarily. Messing with my sleep bigly! Grrrr....
Could be. But it wasn't there before I took the L-Serine.
It seems to have had the opposite effect on Dr. Kats, however. Last night he was turning the Telegram air blue with audio after audio talking about how he was God's gift to humanity (which he is) and no one was donating.
He's got a thing or two to learn about marketing.
I haven’t had a chance to replicate the experiment, yet. This morning I had to drive up to Tempe for a dental appointment, so I decided to heed the “heavy equipment” warning on the L-Serine bottle.
Tomorrow is another day.
A "Josie Holmes" on the Telegram thread says that 12 g of L-Serine helped both her sinus problem and her sleep problem.
Purple towel from manganese. Gross.
Interesting. NAC seems to push out a lot of mucus.
I’m still waiting for Clif High’s Pure Sleep to get back in stock.
Inreresting. I’ve been taking NAC daily for a long time, since I first heard of it on the anti-coof protocols. I ordinarily have no sleep problems whatsoever, but lately I wake up suddenly 5 or 6 times a night now, feeling like I’m either drowning or suffocating. Where does all this mucus come from, I keep wondering, and is there an end in sight? It does happen with my “allergy seasons” (or whatever), and seems particularly aggravated by temperature swings, but this year it’s an absolute beast. And I can’t take OTC meds for it - antihistamines absolutely destroy me.
That purple towel was very striking. For the Cloud9 folks, niacin is a way of expelling bad stuff from your cells, especially from fat cells. After a niacin dose they make sure the body gets rid of the bad stuff, either through sweating or through the GI tract with charcoal assist. They don't want the bad stuff just floating around in your blood or, worst case, migrating to your brain.
I'm already doing hot yoga, though not after every dose! I need to buy some charcoal tablets.
L-Serine replication experiment failed. I still felt pretty good after today’s 3 g dose, but no spontaneous laughter. Maybe it’s like any other addiction — you have to keep taking more and more.
My brother tried 4g (he’s bigger than me). No laughter, but he did say it alleviated a funk he’s been in for the last week or so.
His Chinese wife takes the niacin without a flush moderator — she LIKES the flush. Apparently Chinese women pay to have their cheeks “scraped” because a rosy glow is considered a signal of health. Niacin makes all her cheeks rosy.
I sometimes miss the flush (like when it’s freezing cold in here!) but I don’t flush anymore. Even after taking several days off, all I got was a brief bit of a tingle and warm feeling.
I still get a little flush when I drop 1g niacin and 1g NAC first thing in the morning before coffee. I like it.
L-serine doesn’t taste half bad. It’s a little sweet actually.
500 mg niacin
7.5 mg melatonin
1.3 g L-serine
Flushing like a mofo. I haven’t had a flush to my chest and hands in a while. Whew! Love it.
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