HOM3OSTASIS combines immediate release nicotinic acid (flush NIACIN) + α-LIPOIC ACID (just ‘R’ version is best), as well as Melatonin (as soon as it is comfortable to supplement), along with sufficiency of the other B vitamins (namely pantethine, thiamine, & riboflavin)DOSING (adults):
For therapy, R-ALA (R-alpha-lipoic acid) in relation to Niacin can be in a 1:2 mass ratio of R-ALA:Niacin (e.g. 0.6 g R-ALA + 1.2 g Niacin) to 1:1.5 mass ratio of R-ALA:Niacin (e.g. 0.6 g R-ALA + 0.9 g Niacin), both taken together… Upon feeling better & especially for health maintenance, naturally we will be lowering R-ALA dose on average from the usually higher levels for therapy, and so ratio can then cross 1:>2
If new to niacin, start each dose anywhere from 50 mg up to 500 mg. You MUST experience the flush, which is literally clots being killed, and NOT what is actually acutely bothersome about niacin. Undesirable reactions are simply the excess amount (could even be the majority at first) of niacin (an acidic molecule) moving through vasodilated capillaries (whilst temporarily acidifying exterior blood + tissue cells as it clears) that doesn’t get into cells, until lipoic acid restores cells’ ability to allow niacin in more as you build up (expeditiously but comfortably).
Flush (tingly, inverted sunburn-like feeling w/o pain; body turns red; starts in 10-15 min, peaks 20 min in, cools down thereafter; can last 45 min, unless body is sensitive - add more lipoic acid next dose) is literally clot-killing but still only preliminary mechanism of niacin. The flush (& any undesired acute reactions) will gradually (over next four consecutive doses or so) calm down & completely go away if dosing is continued at least 1x a day (preferably twice to start) as dose continues to be raised towards a 1 g dose (some won’t even need this high ever, while many—less metabolically intact—will benefit growingly with up to 2 g per dose, and a minority enjoy up to even 4 g per dose - don’t do this high unless emergency or comfortable w/ niacin & want to expedite therapy w/ higher dose once it’s getting into cells appropriately). Once flushing doesn’t occur after subsequent sufficient-level dosing, clotting/thrombotic environments (i.e., foundation of inflammation on the surface phospholipid membranes of cells from which it aggregates & accumulates forward) have been cleared (at least in those cells that are at the time able to allow niacin in sufficiently) & will remain at-bay (further anti-inflammatory, antipathogenic, & immune-modulatory pathways/actions of niacin then assume, assuming lipoic acid administration is continuing to promote niacin into cells more)… If you temporarily stop niacin, once restarted, that dose will induce flush response again (never as intense as first time, primarily due to novelty of experience & finally real medicine), meaning micro-clots / new inflammation layers have regathered on cells’ surface membranes since last dose. Here, sufficiently supplementing niacin to overcome & then no longer flush forward, is premier anti-clotting counter. WE WANT MORE THAN ANTI-CLOTTING THOUGH!
To fully enable niacin, we have lipoic acid.
For SERIOUS recovery, may need to reach 1-2 daily doses as high as 600 to 800 mg R-ALA (so anywhere from 900 to 1,600 mg Niacin) per dose; best to build R-ALA + Niacin together at around above-mentioned^ ratio, raising R-ALA as anchor if things aren’t clicking (assuming niacin is near 1 g / enough). Adults for therapy: if one dose for the day, then start around 400 mg R-ALA (some adults may need & experience expedited benefit starting with even higher dose up to 600 mg, usually also as they build niacin up to needed levels (assuming if around / at least 1 g niacin dose); again, note some may not need to get to these levels, so build up at a sufficient but comfortable pace… if dosing 2x daily for therapy: starting at 250 mg but maybe needing to reach 300-400 mg R-ALA per dose (if recovery not clicking after a few days, evaluate raising R-ALA dose, assuming niacin is sufficient with it)
He had radiotherapy for head-and-neck cancer in the early 2000's and had developed a "permanent" bald spot due the radiotherapy. Since he's been doing niacin his bald spot grew back in.
He's also enjoying the L-Serine, as I probably mentioned before. Although I take mine in the morning (with the awesome side-effect of increased happiness), he takes his in the evening. After decades of minimal dreaming he now dreams constantly in Technicolor, with many of his dreams bringing back long-lost childhood memories.