>How does the whole NIATONIN thing work?

Telegram and FR | September 9, 2021 | Dr. Dmitry Kats (interpreted)

[spankalib]

bkmk

[jacquej]

Bookmarking also.

[ConservativeMind]

The author does not know what he is talking about when he says:

“ACE2 aka GPR109A expression”

They are not the same thing, in any form, if “aka” means “also known as.”

[numberonepal]

Moar documentation:

Dr Kats NIATONIN— Podcast and Transcript (early draft of the protocol - it has changed a bit plus language warning)
https://otter.ai/u/-Wx6-rY8F9tFqiaYtLfNuP4vBG4?fbclid=IwAR2UyZaywMx6TUmusG-CziIf86e1TDQKULZ8wfJKZ2z4lVULmBUtikn9J6A

Metal chelating and hydrogen peroxide scavenging effects of melatonin
https://pubmed.ncbi.nlm.nih.gov/12662350/

Melatonin mitigates cadmium phytotoxicity through modulation of phytochelatins biosynthesis, vacuolar sequestration, and antioxidant potential in Solanum lycopersicum L
https://www.frontiersin.org/articles/10.3389/fpls.2015.00601/full

Melatonin prevents oxidative stress resulting from iron and erythropoietin administration
https://pubmed.ncbi.nlm.nih.gov/11273875/

Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells
https://pubmed.ncbi.nlm.nih.gov/27614220/

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
https://pubmed.ncbi.nlm.nih.gov/19781706/

Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization
https://www.nature.com/articles/srep42279?fbclid=IwAR2oV8auLcaByyASFzNwf3P40qgiF31OWEQwqiPd1Ywgnwtosaf3ZrlTSWw

Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells
https://www.jlr.org/article/S0022-2275(20)39224-5/fulltext

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
-Essentially, according to the ACTUAL health science, prion disease / neurodegeneration = accumulative lack of niacin (and melatonin) over the life course... and so can be prevented—as well as even reversed—simply by repleting niatonin.
https://pubmed.ncbi.nlm.nih.gov/25678560/

ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders
https://portlandpress.com/clinsci/article-abstract/135/3/535/227747/ACE2-and-energy-metabolism-the-connection-between?redirectedFrom=fulltext

IMPORTANT —> Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201801951R

Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-021-00915-3

ACE2 and gut amino acid transport.
https://www.unboundmedicine.com/medline/citation/33140827/ACE2_and_gut_amino_acid_transport?fbclid=IwAR2jDQTmbW_QWnJyVFT_AC-LXqA0WI2I-i-W3yQ4RJ39yR0l8lH5ExCxAno

Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms
https://pubmed.ncbi.nlm.nih.gov/25038318/

Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization
https://www.nature.com/articles/srep42279

Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis
https://www.frontiersin.org/articles/10.3389/fimmu.2021.606384/full

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
https://www.nature.com/articles/ncomms4944

NAC Bonus materials
N-acetylcysteine as a potential treatment for COVID-19
https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0074

N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation
https://chemrxiv.org/engage/chemrxiv/article-details/60c753ec4c89190f3bad43ca

N-Acetylcysteine Reverses Anxiety and Oxidative Damage Induced by Unpredictable Chronic Stress in Zebrafish
https://pubmed.ncbi.nlm.nih.gov/29876880/

Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease
https://academic.oup.com/hmg/article/30/7/536/6153421

[numberonepal]

That’s why I put in the notes. Remember, English is not his first language. He means they do the same thing.

[Magic Fingers]

Bkmk

[numberonepal]

Man this is for lay people and English isn’t his first language. That’s why I put replicate in parenthesis. And no one said the store of energy is melatonin.

[numberonepal]

The point is the virus is using the energy from inflammation. If you can give a better layman’s explanation, please do.

[ConservativeMind]

Thank you for giving us some sort of documentation, but none of this seems to describe anyone ever taking 150 mg of melatonin or taking 6,000 mg of flush niacin a day. You have simply given us work that shows NAC, melatonin, and niacin are helpful on their own, but never to your doctor's amount. Your doctor hasn't even done a study with people, or I would assume you would have posted it.

Melatonin starts causing problems at 30 mg. I'm not against going far beyond that, but heck, show a study ever done in the world on 150 mg a day. If you can't, you are the first study participant.

https://www.healthline.com/health/melatonin-overdose

For niacin, the maximum given is 2,000 mg of the sustained release form, but your doctor says to take 6,000 mg a day of the fast flush form. If you can find something that shows 6,000 mg a day of the fast flush form, please present it. If you can't, you are the first study participant.

Look, I have even taken 6,000 mg a day of iodine, which is far beyond the official Upper Tolerable Limit. You have to take selenium and a few other supporting minerals to not cause a problem in your body, but a few studies have actually used this much, and I can point to them.

Don't throw out crazy stuff and encourage people to do stuff no study has ever shown doesn't hurt people. Please.

[numberonepal]

This is a totally new protocol. The point is it’s working swimmingly for thousands of people. If you don’t want to try it, don’t. You aren’t going to find your desired double blind studies yet. They don’t exist.

[ConservativeMind]

Niacin maximum in practice:

https://www.drugs.com/dosage/niacin.html

[numberonepal]

PS I’ve done 300mg of melatonin today with 3000mg of niacin. My biggest takeaway so far is a huge reduction in my smokers cough, less desire to smoke, and a decrease in my ravenous appetite. Some old hip inflammation has vanished. My eyelashes are back to normal since they were reduced after cataract surgery (both eyes). I’m sleeping better than I have in a long time.

You are welcome to wait for a double blind study. For the rest of us not mired in dogma, we’ll be fine. Do try to listen to the interview or at least read the transcript.

[ConservativeMind]

You state, in regard to “Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment,” that:

-Essentially, according to the ACTUAL health science, prion disease / neurodegeneration = accumulative lack of niacin (and melatonin) over the life course... and so can be prevented—as well as even reversed—simply by repleting niatonin.

That study absolutely DOES NOT SPEAK TO MELATONIN—only niacin. You are lying when you say melatonin is part of it, at all.

[ConservativeMind]

I’m NOT TALKING ABOUT STUDIES FOR YOUR STUPID PROTOCOL. I AM TALKING ABOUT ANY STUDY, in the HISTORY OF MANKIND, that EVER USED THESE AMOUNTS OF NIACIN OR MELATONIN.

STOP STATING FALSE ARGUMENTS.

[grey_whiskers]

I'm not blaming you numberone. (No, no SPECTRE reference)

But people beyond the trees are hostile enough, with a bunch of skeptics trying to find any excuse to push the jabs instead of anything else.

So having stuff in bad English, makes it too easy for naysayers to jump in and critique.

I think the translation from scientific techie speak to laypersons, on TOP of translating from a foreign language, is what's doing it -- "doubling" might be "well, cell reproduction is when a cell divides in two, so call it 'doubling' "...that kind of thing.

Be nice to have some friendly biochemists/MDs make their own try, at translating & explaining this.

[numberonepal]

No one ever said it did. I KNOW that varying melatonin dose with niacin intake works for controlling flush. I’ve experienced it and experimented with it and have testimonials from thousands of other people that have done it. You can’t handle anything new. Go back to your white coat dogma and the rest of us will progress naturally and without pharmaceuticals. Good day.

[numberonepal]

Maybe someone should do a study with these amounts. Did that not occur to you?

[ConservativeMind]

Maybe someone should do a study with these amounts. Did that not occur to you?

I have already stated to you that you are the experiment, when it's never been done before.

[numberonepal]

Thanks GW. This is a very complicated physiological scenario. I’m doing my level best to explain it in layman’s terms. I’m a physicist, not an epidemiologist. I’m listening to an epidemiologist and applying my skills to do the research (like having to look up words whose root I am ignorant of). Dogma is what got us into this mess, and I intend to have no part of it. If you don’t wish to try it, don’t. They can take their vaccine and be dead in three years.

[numberonepal]

I have already stated to you that you are the experiment, when it's never been done before.

Kinda like folks being the experiment with the various mRNA vaccines, right? I, and many others, are having quite positive outcomes and having a ball doing it while simultaneously crowd sourcing help for others do it. This is a real world experiment sans the tight laboratory controls the white coats so deeply desire. It's dirty, organic and real which makes it fun.