Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Updated #NIATONIN Protocol for Vax Injury, COVID and Long COVID recovery.
2x daily for adults (mainly for recovery; butyrate will not need to remain this high) - DO THIS AFTER MEALS (lunch & dinner):
800-1600 mg Taurine
+
10-15 mg MELATONIN <— evaluate as per 66.7:1 ratio N:M.
(melatonin supplementation may not be needed here, and instead just at night before bed)
+
3.6-5.0 g BUTYRATE
^ NOTE that a 3.6 g dose corresponds to six (6) separate BodyBio or Butyrex capsules; lower doses can be taken in more mild cases. Remove one pill per day on the third day.
+
200 mcg Selenium (w/ 1st and/or 2nd dose).
Wait 15-45 min (evaluate when is best).
1-3 g NIACIN per comfort/need
Perhaps start at 500 mg if your first time & not an emergency situation (don’t fear flush; try working up to at least 1 g doses as comfortably as possible)
10-15 mg Melatonin before bed at night. Once you wake up, take 1-3 g niacin.
I envy you having fresh aloe vera! Is it hard to grow? I’ve thought of getting some, but with my brown thumb I’d probably kill it!
So I use the bottled gel. But that’s really the only way I’ve been “taking” melatonin at all lately. It readily dissolves in the aloe/colloidal silver mix just by stirring. Slathering it on my skin feels so good after a shower, and any time after I wash my face.
I’ve been taking 1 gram of niacin 2 or 3 times a day. Finally overcame my hesitance to take it on an empty stomach, since I usually don’t eat until I’ve been up for around 4 hours. I’m doing very well and getting a lot done. The energy boost is subtle, but there.
Aloe is easy even for a brown thumb. In fact, any succulent is fairly easy to care for.
In my next batch I will use silver water I make (15ppm) and see what happens.
I had a world-class bowel movement an hour after I took the butyrate, but that could be a coincidence. (I know, TMI.)
People say on the Telegram chat that it’s called “Getting your booty right”.
It’s really pronounced “Butt Irate”, though, IMO (butt no, I haven’t taken any!) ;-)
I think I know where all my excess cholesterol went. I now have Y-pattern acne, on my shoulders, down the middle of my chest to the top of my stomach. The cholesterol is being excreted through my pores.
Same here. I've never ever had acne on my back or chest. I broke out at high doses.
OMG! First day trying this and I’m on FIRE RIGHT NOW! Good gawd! This is NOTHING like a hot flash. Guess this means I need to up the melatonin. Wow.
Stay with the 66.7:1 ratio. Take some extra mellie to help control the flush. Are you doing the butyrate?
You can get NAC from pipingrock.com
How do you take NAC?
You can remove it from the cap and dissolve it. You can take with niacin. It is more bitter than niacin however.
It’s always the worst at the beginning. It gets better if you persist. How much did you take? I flushed like crazy with only 300mg at first. I was convinced I’d never be able to take more niacin than that. I played around with increasing the dosage very incrementally each time, along with large doses of melatonin (like 1/2 as much as the niacin), and managed to reduce the flushing to just my head and neck, and then only tingling. But it wasn’t until I did the counter-intuitive thing - the 66.7:1 ratio, even with much more niacin, that I got it down to a tiny, barely noticeable tingle, or nothing at all. That was about 3 weeks in, IIRC. I don’t know if it was something about that ratio, or my body was just getting used to niacin supplementation. It sounded so strange and contrary, but it worked! Now I take 1000mg niacin 3 times a day without even thinking about it, and no issues.
So the niacin flush is -not- like a hot flash? I was wondering about that. What’s the difference? Turning red? I went through menopause 20 years ago but never experienced hot flashing, so I thought the niacin flush was the closest I’d get to it.
I just take the NAC with my other vitamins, and swallow the cap. It smells so sulfuric, I don’t think I’d want to open it.
Speaking of smells, I told my husband about butyrate. He has IBS, and I told him it might help and he was intrigued and ordered some. We’ll see what he reports.
*I did not warn him about the smell. Tee-hee!
I bought the powder. Maybe I’ll fill my own capsules.
The niacin flush is nothing like a hot flash but probably as close as you can get. I prefer the flush to the flash, haha! The flush is more of a skin heat/tingling, whereas hot flashes are from the inside and make you look around for the nearest fan! (I’ve got fans on 6 inch centers right now). I think it was Salamander who commented to me once that “you know you’re having a hot flash when you’re in a bikini sitting in a snow bank!” HAHAHAHA!! Never forgot that.
Yesterday was my first day, and I only took it once. I didn’t get the bulk stuff, but bought some pills from my on-line source (pipingrock.com), so they do have some additives, etc. Yesterday was 500mg Niacin and 12mg melatonin and I flushed like crazy (kinda like it, actually). Beet red forearms/face etc that lasted maybe half an hour. This morning I doubled the M to 24 mg and kept the N the same, still flushed but not as intensely as yesterday. Eating lunch right now and will take my regular vitamins, wait a couple hours and then do the N/M combo around 2 my time (pacific coast). This time I’m going to increase the M again and see what happens. I didn’t get the butyl stuff (or whatever it’s called) didn’t see that in the original post, and I went off that. Just now managed to get through the entire thread up to post 338 and have to keep reading from there. I’m most interested to see if this might help with tinnitus. Hubby has it bad and so far nothing helps. I feel so bad for him ‘cause it can drive you crazy at times.
I recall reading quite a few mentions of tinnitus in the Niatonin thread on Telegram. If you have Telegram, you can go there and use the magnifying glass icon to enter a search tor the word tinnitus, and all references to it in the very very long chat thread will come up together.
I just did that! TONS of people saying they’ve either cured it, or GREATLY reduced it. Just texted hubby that he may want to try it. He was a little worried when I told him about my flush yesterday. Not sure about all this stuff I’m taking. I’m just trying to find better health and mainly something to battle my arthritis. I’m not giving up my guitar until I absolutely HAVE TO. And 56 is WAY too young to be giving up!
By the way, I had the bliss experience after acupuncture again yesterday. I was able to coax it along with expressions of gratitude for half an hour. Gratitude seems to feed the feeling. I mentally say to myself, “Thank you, so-and-so, for being a part of my life.”
I never had this before despite many acupuncture treatments. Since I’ve been on Niatonin, it’s happened 3 out of 4 times.
Afternoon report: 36mg of M/500mg of N. Flush not NEARLY as intense. Think I’m almost there. Will maybe cut M pill in half tomorrow morning and do 42/500, see how that works.
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