Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Imma go out and cut some aloe and give it a try.
“DO NOT OPEN THE BUTYRATE CAP!”
ROFL! Sorry, laughing with ya, not at ya! That stuff is, er, powerful!
That stuff is, er, powerful!
I hope it’s a passing fad, and goes the way of the other has-been cofactors that have come and gone, but he sounds awfully serious this time! This is where I’m gonna have to draw the line, I think!
And I’ve gotta love how Dmitry writes “Why does no one ever comment on the literature I post?” LOL Ummm, maybe because all that biological jargon looks like a foreign language to 99% of us? I know it does to me!
>I’m afraid of butyrate now after reading all this.<
I’ve found butyrate to be quite helpful, frankly. Does it have an odor? Yes, but I pour the capsules into the bottle’s cap and take them with a glass of water. Originally, I had a way harder time with getting used to the flush.
Butyrate definitely has a positive influence on overall health, at least in my experience.
You can’t smell it through the capsule thank goodness. I was dumb enough to open it.
Keep doing what you’re doing. Kats is focusing on people that had a hard time with melatonin sweet spots who were woefully undernourished. We know the original approach works fine. However, the butyrate will most defiantly help with flushing if taken with the NIATONIN, but not necessarily in the large doses he’s currently recommending.
Again, Kats somehow believes that everyone understands what’s in his head. It’s a sign of what I call “blind genius”. I’ve seen it many times over my career. He’s not all that great at documentation and explanation. A light bulb goes off in his head and he thinks everyone should understand it. He is NOT a good teacher.
Yes. The butyrate helped us in the transition to pistachios, then again transitioning to the 66.7:1 ratio. We’re down to a maintenance dose of 15M/1000N at night and 1000N one other time in the day. I figure the long term effects are going to be just as good as the therapeutic doses.
With no ill effects, I stepped down from 3000N by 500 at a time. I’m now at 1000N, but still with pistachios for the morning dose. Tomorrow I try the 15M/1000N formula.
My butyrate won’t arrive until 10/29. I promise not to mix it with the Halloween treats.
I had my annual physical yesterday, with labs done last week. Total cholesterol is down, LDL (bad) is down, HDL (good) is up, and the cholesterol/HDL ratio is way down.
Since I had no health problems, I had plenty of time to talk to the physician assistant about COVID etc. She had heard vaguely of the potential of ivermectin, but she didn't even know it was a retargeted anti-parasitic. She was surprised to hear about the melatonin/niacin combination, but she confirmed that may improvement in blood lipids was probably due to the niacin. I gave her way more information about ivermectin and Niatonin than she wanted to know.
Health-wise this has been a great year for me. My blood pressure has gone down 20 points thanks to the wolfberry puree I've been drinking, my blood lipids have improved substantially thanks to Niatonin, and my back's feeling great thanks to the new inversion table. It's Getting Better all the time.
Bkmk
Just be my luck if I tried this I’d get a flush at the same time as a hot flash and probably explode! I find it interesting for the anti-inflammation properties though. As a guitar play with arthritis slowly creeping in, I’m looking for anything that doesn’t include big pharma products.
Don't forget about CBD.
The niacin might actually help with the hot flashes. You aren’t going to explode. LOL.
Great news!
Hahahaha! I did purchase what you recommended. Hubby’s gonna think I’m crazy I’ve bought so many supplements in the last year.
Hahahaha! I did purchase what you recommended. Hubby’s gonna think I’m crazy I’ve bought so many supplements in the last year.
I did my first butyrate today — 2 grams.
At the same time I opened the bottle, my wife opened the sliding glass doors to the back yard. I noticed a “scent” that reminded me of a time when I worked in an office building surrounded (at that time) by farmland. Every year the farmer would spread manure on his spread, and the fragrance would dominate the senses for days. Momentarily I blamed the smell on the open door, but then I realized it came from the bottle.
I’m now melatonin-free. I just sip the 1000N + 24ozH20 slowly.
I had a world-class bowel movement an hour after I took the butyrate, but that could be a coincidence. (I know, TMI.)
That TMI is important information. You can learn a lot from poop.
I’m on to maintenance dose of 15M/1000N before bed. I’m pretty sure if I upped my exercise I’d feel better than ever, but I’m lazy. I’m committed to keeping an extra layer through this winter anyway in case it’s needed (and it looks like it will be).
So I mixed some M in aloe juice I made from yard aloe vera. Wow does that stuff sink in fast. I’ll report back on whether it helps sun spots on arms and legs.
40g aloe vera pulp
59g distilled water
1g melatonin
Put it all in the NutriBullet, and voila a 1% melatonin solution!
And proudly proclaim "I'm not sick". Something is working.
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