Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
This does not make sense to me. How is it that I can take niacin, it goes into my stomach, and then the first place I feel a tingle is my ears? Sometimes within 5 minutes? How does it get there? There is not even much blood in the ears, it’s mostly cartilage. And in 5 minutes? Just trying to imagine by what mechanism this is even possible.
I just completed 3 weeks. As circumstances would have it, I was able to reach 1200 N on Saturday. But that’s because on both Friday and Saturday, I actually had the free time after meals to do 2 doses - so the 1200 was split between them.
I decided to play around with ratios, since there seemed to be no rhyme nor reason to the ones I’d been trying lately and what their results were:
Friday after brunch, 250M/300N; and after supper 100M/400N.
Saturday after brunch, 200M/700N; and after supper 200M/500N.
Both times Friday and after brunch Saturday I had light tingling on the ears, face and neck. After supper Saturday, there was nothing. Yay! (I was surprised!)
Sunday I was back to my usual once a day, and took 200M and 700N, and had slight tingling again.
OK, the 500mg with 1/4 cup of pistachios made a flush just about like the first time. Not fun but not terrible. My powdered melatonin came yesterday but the scale won’t be here until tomorrow. No matter what, I really want to stay around 250-300mg of Niacin once a day. I’ll take some convincing to do otherwise, at least for a while.
You’ll be amazed when you go beyond 1000 mg.
For me, a little food, a quarter cup of pistachios, and then the niacin in 12 oz of warm water, sipped slowly, seems to work. I know everyone’s different, however.
Most meds and supplements effect me twice as much as they do other people so I normally take the minimum of everything. Niacin has always made me nervous for some reason. I’m not sure why. I have an appointment for bloodwork in February and if the lower dose doesn’t show up as a problem somewhere I might increase it.
This time was a little different. The first time I only took about 150mg and had an intense flush. On Sunday I took 250mg and 1/4 cup of pistachios and didn’t have any flush. This time I took 500mg with 1/4 cup of pistachios and had a similar flush as the first time but it lingered in a strange way. When it started to go away there was itching and chills. My skin stayed sensitive for longer.
I might do 250mg with half as many pistachios next time and see how that does.
Soak a cup of pistachios for 12-24 hrs. Drain, then blend with 2 cups milk. If you have kitchen scales weigh out 200g of that smoothie. That should be around 66 stachios. Do maffs for other amounts. You have to get to 1500-2000N twice or thrice a day for therapeutic effects to really kick in.
🤣 probably wasting my time then. No way this body can take that much.
That slow sipping is something to consider. I find I have less chance of flush if I do that. I’m talking like 5 mins rather than gulping down all that niacin at once.
You should really try the pistachio “smoothie”. It’s a lot easier to get them in that way. The soaking will make for a smoother drink and wash away unwanted salt. I forgot to add in my previous post to add some honey (like 2T) to the blender. I chose one cup pistachios and 2 cups milk because it’s easy to do the math as this ends up being right around 600g.
Another thing is that eating the pistachios will bring down your mellie requirements fairly quickly. I was downing a half cup of pistachios for 2000N, but now it’s more like 1/3. I’m not flushing so I may be able to go lower.
It sounds counterintuitive, but the higher doses of niacin will result in less flush if you ratio the same mellie.
It can if you get enough mellie in. You’re in the squirt gun range and you want to be in the firehose range.
When I was still doing the pure melatonin, I began to think that a ratio didn’t describe the relationship. It’s more like the body needs a certain dose of melatonin to get things started (maybe absorbed by the intestinal bacteria) and then the ratio applies after that.
I put some pistachios in my fruit smoothie the other day. It was... interesting. Okay, however I wasn’t used to any salty taste in fruit smoothies.
But I hate milk.... gakkk! Haven’t consumed any since elementary school!
I'm in the garden hose range, according to the meme. When I get to the fire hose range, I fear I'm going to be levitating off the acupuncture recliner, like Snuffles:
I do it in my smoothie too but it kills most of the sweet.
Kats had some people try 15mg mellie and 1000mg niacin at the same time in one glass. No pistachios involved here. They are saying they didn’t flush but it seems to be veterans trying it. It sounds promising for a daily dose after going to therapeutic levels and back.
I did 1412N tonight (because I didn’t want to scoop off 12 mg from the pile of niacin). Just had a few pistachios beforehand. Seems like there’s a form of pistachio persistence.
I’m taking about 1.5 oz (by weight) of pistachios per day. I’ll start cutting back on P when I reach 2000N to see what I really need.
Are people seeing benefits from going beyond 2000N?
I’ve read where people frequently speculate that you just get used to the niacin over time and don’t flush any longer, so the melatonin doesn’t make that much difference to the flushing issue, if any. This evidently happened with people who were on the niacin protocol before it became the niatonin protocol.
I tried another experiment tonight. 200M and 800N. But this time, knowing I’d likely get tingles, I prepared for it. I took a dollop of aloe vera gel, and mixed in a smidgen of melatonin powder until it dissolved. I massaged this into my skin in all the usual places that got tingles. Ears, face, neck, shoulders. And it really helped! And I know I was tingling because this time, I only felt it *inside* of my ears (that was a first!), the one spot I didn’t put the gel! Also, my eyes dried out, like they usually do when I tingle. So that’s another way to get melatonin to work. Interdasting!
That’s cool about the melatonin skin treatment.
I just wondered whether pistachio butter was a thing. It turns out that both Walmart and Safeway have it, though (at least in Walmart’s case) it’s mixed with walnut oil and salt.
Interesting. I’ve made a melatonin, niacin and hyaluronic acid castor oil lotion for other purposes. If I flush on a dose I’ll try it out.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.