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Metal exposure from environmental pollution is associated with increased buildup of calcium in the coronary arteries at a level that is comparable to traditional risk factors like smoking and diabetes, according to a study. The findings support the fact that metals in the body are associated with the progression of plaque buildup in the arteries. Atherosclerosis is a condition where the arteries become narrowed and hardened due to a buildup of plaque. It's an underlying cause of heart attacks, strokes and peripheral artery disease (PAD), the most common forms of cardiovascular disease (CVD). Atherosclerosis causes coronary artery calcium (CAC). Researchers...

According to researchers, 80% of patients with previously untreated or relapsed/refractory advanced-phase chronic myeloid leukemia (CML)—including both accelerated or myeloid blast phases of the disease—or Philadelphia chromosome-positive acute myeloid leukemia (AML) achieved a bone marrow remission when treated with a novel combination of decitabine, venetoclax and ponatinib. Findings from the Phase II clinical trial represent an important step forward for patients with advanced-phase CML, who tend to have poor outcomes. "Over the last decade, there have been very few studies that evaluated a regimen to treat this rare disease and identify a potential standard-of-care treatment," said Nicholas Short, M.D. "It...

When John Huston's crew arrived on the island of Tobago in September of 1956 to begin filming his new picture, Heaven Knows, Mr. Allison, 20th Century Fox were hoping that it would repeat the massive success of The African Queen – another story about a mismatched couple stranded in the wilderness, pitted against a well-armed enemy in a backwater of a global war. It was a war picture, but a decade since World War Two had ended these had gone from propaganda pictures (Bataan, Destination Tokyo) to gritty dramas full of battle scenes (Battleground, 12 O'Clock High) to adventure pictures...

Physical buttons are increasingly rare in modern cars. Most manufacturers are switching to touchscreens – which perform far worse in a test carried out by Vi Bilägare. The driver in the worst-performing car needs four times longer to perform simple tasks than in the best-performing car. The screens in modern cars keep getting bigger. Design teams at most car manufacturers love to ditch physical buttons and switches, although they are far superior safety-wise. That is the conclusion when Swedish car magazine Vi Bilägare performed a thurough test of the HMI system (Human-Machine Interface) in a total of twelve cars this...

DETROIT, MI — Famed talk show host and meme subject Oprah Winfrey was showered with accolades today after last night's release of a moving 1-hour special on the dangers of alcohol abuse. According to viewers, Winfrey sat down with one of America's most well-known drunkards for an interview, presumably in a thinly veiled attempt to warn Americans just what might happen if they also succumb to the siren call of the bottle. "It was a really powerful show," recalled Oprah fan Jack Morley. "I watched it as Oprah went through and hammed it up with whoever that other completely sozzled...

Glioblastoma is a particularly aggressive brain tumor that at present is incurable. Half of patients die within twelve months of diagnosis. Drugs that are effective against brain tumors are difficult to find, as many cancer drugs often can't cross the blood-brain barrier to reach the brain. Researchers have now found a substance that effectively combats glioblastomas, at least in the laboratory: an antidepressant called vortioxetine. Scientists know that this inexpensive drug, which has already been approved by agencies such as the FDA in the U.S. and Swissmedic, is capable of crossing the blood-brain barrier. With pharmacoscopy, researchers can simultaneously test...

An ambitious effort to understand the Earth’s climate over the past 485 million years has revealed a history of wild shifts and far hotter temperatures than scientists previously realized — offering a reminder of how much change the planet has already endured and a warning about the unprecedented rate of warming caused by humans. The timeline, published Thursday in the journal Science, is the most rigorous reconstruction of Earth’s past temperatures ever produced, the authors say. Created by combining more than 150,000 pieces of fossil evidence with state-of-the-art climate models, it shows the intimate link between carbon dioxide and global...

The Washington Nationals demoted All-Star shortstop CJ Abrams to the minor leagues after he stayed out all night at a Chicago-area casino, leaving only hours before a Friday day game against the Chicago Cubs, sources told ESPN's Jesse Rogers. Abrams, 23, led off for the Nationals and went 0-for-3 with a walk and strikeout in Friday's game, which started at 1 p.m. CT. He was informed of the demotion Friday night, sources said. He will be sent to West Palm Beach, Florida, home of the Nationals' minor league complex. Because Abrams has been with Washington for the entirety of the...

Elon Musk is encouraging a hilarious parody ad mocking Kamala Harris to go viral on X after California governor Gavin Newson signed a law to eliminate deepfake and other AI generated content in the lead up to the election. The law was sparked by a series of parody videos created by AI and using deepfakes to mock Kamala Harris on social media. https://www.youtube.com/watch?v=NIz-aoZFzM4

Vice President Harris offered effusive praise for Sean “Diddy” Combs while participating in a town hall dedicated to the coronavirus and black Americans. The two-hour event in April 2020 was co-hosted by CNN political commentator Van Jones and also featured Rev. Al Sharpton and “Squad” members Rep. Alexandria Ocasio-Cortez (D-Bronx) and Rep. Ayanna Pressley (D-Mass.) “Hey everyone, it’s good to be with you this evening. Sean I want to thank you because you always have a way of convening and bringing folks together,” Harris said on the call. She later followed up in an effusive tweet that was widely mocked...

A team of epidemiologists has shown experimental evidence of an inverse relationship between incidences of Alzheimer's disease and colorectal cancer. The group found that mice with Alzheimer's-like symptoms were less likely than control colorectal mouse models to develop colorectal cancer. For years, doctors have been noticing that people who develop Alzheimer's are less likely to develop certain types of cancers, mostly particularly, colon cancer. They have also noticed the reverse; colorectal patients seem to be less likely to develop Alzheimer's disease. For this study, the researchers ran experiments with mice to find out whether an association exists. The researchers administered...

Explanation: The defining astronomical moment of this September's equinox is at 12:44 UTC on September 22, when the Sun crosses the celestial equator moving south in its yearly journey through planet Earth's sky. That marks the beginning of fall for our fair planet in the northern hemisphere and spring in the southern hemisphere, when day and night are nearly equal around the globe. Of course, if you celebrate the astronomical change of seasons by watching a sunrise you can also look for crepuscular rays. Outlined by shadows cast by clouds, crepuscular rays can have a dramatic appearance in the twilight...

A single treatment session, which includes the video game Tetris, can reduce symptoms of post-traumatic stress disorder (PTSD). "With just one guided treatment session, we saw positive effects that persisted after five weeks and even six months after treatment. The researchers focused on getting rid of flashbacks. By replacing intrusive memories using a visual task, other PTSD symptoms can also be reduced. The treatment is based on what is known as mental rotation, which lies at the heart of Tetris. When you look at an object from one angle, you can imagine what it would look like if it were...

In Eastern Nebraska, far from the presidential battleground states, a drama is playing out that could, in a perfectly plausible November scenario, have history-altering repercussions for the nation’s future and the next president — and it may all come down to one man. A single Republican state senator from Omaha, Mike McDonnell, has so far stood firm against a push by former President Donald J. Trump, national Republicans and the Nebraska G.O.P. to change Nebraska from a state that divides its electoral votes by congressional district to one that awards all of them to the statewide winner. Maine is the...

Vice President Kamala Harris has accepted CNN’s invitation for an Oct. 23 presidential debate, with her campaign calling on former president Donald Trump to do the same. “Donald Trump should have no problem agreeing to this debate,” Harris campaign chair Jen O’Malley Dillon said Saturday in a statement. “It is the same format and setup as the CNN debate he attended and said he won in June, when he praised CNN’s moderators, rules, and ratings.” Trump, who debated Harris on Sept. 10, has so far said he is not interested in another debate. Trump has claimed he won the debate...

MOUNT PLESANT, S.C. (WCIV) — An altercation at a Chipotle in Mount Pleasant led to the arrest of one, according to the Mount Pleasant police Department. Officers arrived to the scene of the reported assault Monday afternoon, and located the suspect, assistant manager of the location, Jaqueennia Loyd. Loyd appeared to officers as being visibly upset and agitated. She reported to officers that she was working in the kitchen when a disgruntled customer came in wanting to know where the rest of their order was. Loyd explained to the unidentified male that the order would be out when it was...

Republicans spent two years sabotaging the U.S. House. Another two years would be ruinous.The Lord works in mysterious ways. Six weeks after his improbable rise from obscurity to speaker of the House in late 2023, Louisiana’s Mike Johnson decided to break bread with a group of Christian nationalists. He gave the keynote address (at the Museum of the Bible) to the National Association of Christian Lawmakers, a group whose founder, “proud” Christian nationalist Jason Rapert, has said: “I reject that being a Christian Nationalist is somehow unseemly or wrong.”Rapert’s organization promoted the pine-tree “Appeal to Heaven” flag, which was among...

Entertainment legend Oprah Winfrey held a star-studded town hall for Vice President Kamala Harris on Thursday. It took place in Farmington Hills, Michigan, in a key swing state, but celebrities from around the world connected via Zoom to help celebrate Harris’s last-minute candidacy for president. Meryl Streep, Julia Roberts, Chris Rock, Jennifer Lopez, Ben Stiller, and others joined in.

Finnish is known for its challenging grammar and vocabulary, which can be daunting for learners. It features a complex system of cases—15 in total—which can change the endings of nouns based on their function in a sentence. Additionally, Finnish is a language isolated from other European languages, so there are few cognates for English speakers to rely on. Nevertheless, Finnish is a language worth learning for its unique position in the world. Finland boasts a high standard of living, stunning natural landscapes, and a rich cultural history. Learning Finnish can enhance your experience if you plan to travel or work...

[H/T Grey_Whiskers]I cannot make it clear enough how important this is. And how important it is that the American people SEE THIS.For a very long time, many Americans were under the impression that the CDC would not do a Vacc*nated vs. Unvacc*nated study on the health outcomes of our children. But, They actually did, back in 1999.Why didn’t we know? Because the results were so d@mning against va((ines, that they deliberately hid it from the public.But thanks to Robert F. Kennedy Jr. and the Children's Health Defense, they were able to obtain the records through a FOIA request several years...