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Study Suggests Benefits of Vitamin C for Severe Sepsis
The Cleveland Clinic ^ | Jan 8 2020 | Cleveland Clinic

Posted on 02/20/2020 12:38:21 PM PST by Norski

More than 1.7 million Americans develop sepsis every year and incidence of the condition is on the rise. In severe cases, widespread inflammation leads to multiorgan failure and death. Results of a new study hold the tantalizing prospect that, for some patients with sepsis, intravenous (IV) vitamin C could increase survival and shorten intensive care unit (ICU) stays.

The findings, published in JAMA, are from the CITRIS-ALI (Vitamin C Infusion for Treatment In Sepsis-Induced Acute Lung Injury) trial. Cleveland Clinic was one of seven enrollment sites across the country chosen for the study because of the diversity of its patients and the number of cases of sepsis it sees.

Conducted from September 2014 to November 2017, CITRIS-ALI was the first randomized, double-blind, placebo-controlled multicenter trial to assess vitamin C and its potential impact on sepsis and acute respiratory distress syndrome (ARDS).

“We hypothesized that IV administration of vitamin C would lead to a decrease in inflammation, and hence, improved outcomes,” said co-author Abhijit Duggal, MD, MPH, MSC, Director of Critical Care Research. “But the organ dysfunction scores and inflammatory markers in patients who received vitamin C was not much different from that in the placebo group. However, there were significant differences in the hard outcomes of mortality and length of stay.”

(Excerpt) Read more at consultqd.clevelandclinic.org ...


TOPICS: Health/Medicine; Science
KEYWORDS: c; corona; covid; cytokine; health; miracles; sepsis; shock; vitaminc; vitc
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1 posted on 02/20/2020 12:38:21 PM PST by Norski
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To: Norski

“Patients in the control arm were much more likely to die within the first three to five days in the ICU than were the patients on vitamin C. The mortality benefit associated with vitamin C seemed to continue for the duration of the ICU course,” says Dr. Duggal.


2 posted on 02/20/2020 12:40:01 PM PST by Norski
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To: Norski

Vitamin C is an anti-oxident. Good for many things health wise. You cant take in too much. No downside to taking it.


3 posted on 02/20/2020 12:42:35 PM PST by Magnum44 (My comprehensive terrorism plan: Hunt them down and kill them.)
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To: Magnum44

Yes. More here:

https://www.evms.edu/about_evms/administrative_offices/marketing_communications/publications/issue_9_4/sepsis.php?utm_source=digital_magazine&utm_medium=web&utm_campaign=sepsis_resources&utm_content=media#media-professional


4 posted on 02/20/2020 12:48:19 PM PST by Norski
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To: Magnum44

Yes...wonder what it would do for corona virus??? I take 10,000 a day at least...


5 posted on 02/20/2020 12:49:34 PM PST by goodnesswins (Want to know your family genealogy? Run for political office...")
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To: Norski

Dr. Mercola has been saying this for a while on his website - a protocol of IV Vit C, thiamine and hydrocortisone for sepsis.


6 posted on 02/20/2020 12:51:40 PM PST by GnuThere
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To: Magnum44

unless taken orally then it can lead to a serious need for bathroom facilities.


7 posted on 02/20/2020 12:51:47 PM PST by reed13k (For evil to triumph it is only necessary that good men do nothing)
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To: Magnum44

You actually can take too much, such that a counter-inflammatory response is created.

Everything needs to be balanced; here there is severe inflammation, so high dose is indicated.

In normal life, about 500mg/day is probably right, although some say up to 1000/mg divided into two doses is good.


8 posted on 02/20/2020 1:11:03 PM PST by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem)
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To: goodnesswins

Yes...wonder what it would do for corona virus??? I take 10,000 a day at least...

— — — —

Quite a bit, I suppose. It is the reason I have posted the information.


Prevention Through Public Education and Natural Product Utilization (Excerpt)

People with Acute Respiratory Distress Syndrome (ARDS), SARS, and cytokine storms, do best when treated with a variety of antioxidants. Nathens et al showed that critically ill patients treated with vitamin C and E antioxidants suffered fewer multi-organ failures than others treated without these vitamins.

According to Heyland et al, antioxidants, particularly selenium, lowered death rates among critical care patients. DeFlora et al., showed that nutritional supplementation with N-Acetyl-Cysteine (NAC), a precursor of the antioxidant glutathione, significantly reduced flu patients’symptoms.

Lock and other medical doctors published that acetaminophen or paracetamol (Tylenol, Panadol) depletes glutathione in the body, while ibuprofen (motrin) does not. . . “

Source Article: Protect Yourself From Death By “Cytokine Storm”

https://www.preventdisease.com/news/09/111609_protect_yourself_cytokine_storm.shtml


9 posted on 02/20/2020 1:17:24 PM PST by Norski
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To: goodnesswins

Vitamin C comes from China too!

Japan did a study that showed high dose vitamin D helps to prevents the flu.


10 posted on 02/20/2020 1:29:23 PM PST by lizma2
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To: lizma2

What doesnt?


11 posted on 02/20/2020 1:39:19 PM PST by goodnesswins (Want to know your family genealogy? Run for political office...")
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To: lizma2

Actually I have some Liposomal Vit C that IS made in USA


12 posted on 02/20/2020 1:40:34 PM PST by goodnesswins (Want to know your family genealogy? Run for political office...")
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To: Norski

Anecdotal reports of this successful treatment have been floating around for a few(?) years


13 posted on 02/20/2020 1:40:40 PM PST by Oscar in Batangas (January 20, 2017, High Noon. The end of an error.)
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To: Norski

Well, it sure doesn’t take long to prove up the control group in a study does it.


14 posted on 02/20/2020 1:40:55 PM PST by Sequoyah101 (We are governed by the consent of the governed and we are fools for allowing it.)
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To: lizma2

Well..I do take 8-10,000iu vit D in winter, too...with vit K


15 posted on 02/20/2020 1:41:57 PM PST by goodnesswins (Want to know your family genealogy? Run for political office...")
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To: Oscar in Batangas; ncpatriot

Yes, 2017, more articles 2018. Not at the top of the money-making articles online. . .


16 posted on 02/20/2020 1:54:04 PM PST by Norski
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To: goodnesswins

Liposomal Vit C

Thank you.

I’ve taken 10,000 D last 2 winters and didn’t catch any of the bugs that went around the office.


17 posted on 02/20/2020 1:55:09 PM PST by lizma2
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To: Sequoyah101

Not if they are at death’s door, I suppose.

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

A Retrospective Before-After Study

https://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext


18 posted on 02/20/2020 2:02:42 PM PST by Norski
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To: GnuThere

Dr. Mercola. Yes. Thank you for reminding me.

I have not kept up on these items for the last year or two, and so was not aware that the sepsis protocol was now being used and discussed.

https://articles.mercola.com/sites/articles/archive/2019/12/16/vitamin-c-health-effects.aspx

It is helpful to see a link to remain current.


19 posted on 02/20/2020 2:15:02 PM PST by Norski
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To: Jewbacca

“In normal life, about 500mg/day is probably right, although some say up to 1000/mg divided into two doses is good.”

Linus Pauling, et al, would disagree.


20 posted on 02/20/2020 2:18:25 PM PST by Magic Fingers (Political correctness mutates in order to remain virulent.)
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