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Ketamine for Depression: The Most Important Advance in Field in 50 Years?
Time Healthland ^ | 10-05-2012 | Maia Szalavitz

Posted on 10/06/2012 4:37:30 PM PDT by Renfield

In any given year, 7% of adults suffer from major depression, and at least 1 in 10 youth will reckon with the disorder at some point during their teenage years. But about 20% of these cases will not respond to current treatments; for those that do, relief may take weeks to months to come.

There is one treatment, however, that works much faster: the anesthetic and “club drug” ketamine. It takes effect within hours. A single dose of ketamine produces relief of depression that has been shown in studies to last for up to 10 days; it also appears to reduce symptoms of bipolar disorder and suicidal thoughts. Now, a new research review published in Science calls the discovery of these effects of ketamine, “”arguably the most important discovery in half a century” of depression research....

(Excerpt) Read more at healthland.time.com ...


TOPICS: Health/Medicine; Science
KEYWORDS: depression; ketamine; medicine; pharmaceuticals
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1 posted on 10/06/2012 4:37:36 PM PDT by Renfield
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To: Renfield

Maybe the reason so many people are DEPRESSED is because we are living through a DEPRESSION.


2 posted on 10/06/2012 4:39:20 PM PDT by UCANSEE2 ( If you think I'm crazy, just wait until you talk to my invisible friend.)
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To: UCANSEE2

Barack would prefer that you take the pain pill and let him continue on screwing the taxpayers and raping the Constitution.


3 posted on 10/06/2012 4:43:22 PM PDT by a fool in paradise (Obama likes to claim credit for getting Osama. Why hasn't he tried Khalid Sheikh Mohammed yet?)
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To: Renfield

This is what they use to tranquilize horses, right? So a good dose removes depression for 10 days by rendering you unconscious for that period.


4 posted on 10/06/2012 4:49:13 PM PDT by bigheadfred (wowza)
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To: Renfield
Soma® for you, Citizen !
5 posted on 10/06/2012 4:50:34 PM PDT by tomkat
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To: Renfield

Send that depression down the K-Hole.


6 posted on 10/06/2012 4:54:25 PM PDT by Pearls Before Swine
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To: Renfield
Hard to see how halalucinaitng and being incapacitated for hours can be an improvement over depression, unless the benefits persist long after the side effects wear off.
7 posted on 10/06/2012 4:56:56 PM PDT by BenLurkin (This is not a statement of fact. It is either opinion or satire; or both)
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To: bigheadfred

So a good dose removes depression for 10 days by rendering you unconscious for that period.”

Maybe we should slip some to Matthews and all the other Dimwits that were so depressed after BO lost the first debate. Silence for 10 days would be golden indeed.


8 posted on 10/06/2012 5:02:30 PM PDT by Grams A (The Sun will rise in the East in the morning and God is still on his throne.)
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To: Renfield
Well, now we know what the next fad in substances-of-abuse will be.

I remember when Time and Newsweak ran similar articles on the wonders of Ecstasy.

9 posted on 10/06/2012 5:04:57 PM PDT by E. Pluribus Unum (Government is the religion of the psychopath.)
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To: bigheadfred

My son was seriously injured in Afghanistan 18 months ago, and he was kept in a coma for 8 days with ketamine. I thought it was for the pain, since just about every bone in his lower back down to his toes was broken.

Whatever it was for, the outcome in the end was fine. But when he did come around, there were some very weird things coming out of his mouth!


10 posted on 10/06/2012 5:05:02 PM PDT by kevslisababy
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To: tomkat

Exactly......There is no help for “hopelessness” except “hope”. (God). You drug people to cover up their “emotions” which is NOT help...........it is what they do to the old people in nursing homes-—drug the masses, so it takes little work to deal with them and their problems and they are quiet.

Think of all the drugs people 40 and over take....just like Soma-——emotions are NOT TIED TO BEHAVIORS; they are CAUSED BY A PILL. It is evil.

How inhumane is that—to disconnect emotions from behavior.

Brave New World and/or 1984.


11 posted on 10/06/2012 5:05:09 PM PDT by savagesusie (Right Reason According to Nature = Just Law)
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To: Renfield
Know the facts.

12 posted on 10/06/2012 5:06:11 PM PDT by I see my hands (It's time to.. KICK OUT THE JAMS, MOTHER FREEPERS!)
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To: bigheadfred

I might point out that winning the Lottery removes depression for as long as the money holds out.


13 posted on 10/06/2012 5:18:10 PM PDT by UCANSEE2 ( If you think I'm crazy, just wait until you talk to my invisible friend.)
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To: UCANSEE2

0bama has sent numerous conservative elderly Americans to an early grave due to a prolonged forced tolerance of his unacceptable comments and unconstitutional actions. Stress kills.


14 posted on 10/06/2012 5:21:22 PM PDT by Obama_Is_Sabotaging_America
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To: Renfield
To anyone interested, St. John's wort (Solaray 2x/day) ia a godsend for moderate depression and sleep issues
15 posted on 10/06/2012 5:21:43 PM PDT by bramps
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To: bigheadfred
It's used in veterinary medicine as a paralytic drug. For instance for equine castrations they sedate the horse and then give him ketamine to keep him still and down until the deed is done. Putting a horse totally out in the field is not done. Horses are too fragile coming out of anesthetics to be done in an uncontrolled setting.
16 posted on 10/06/2012 5:22:29 PM PDT by Himyar
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To: E. Pluribus Unum

That fad went over back in the 1990s. Its street name is “Special K”.


17 posted on 10/06/2012 5:22:33 PM PDT by Squawk 8888 (True North- Strong Leader, Strong Dollar, Strong and Free!)
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To: a fool in paradise

18 posted on 10/06/2012 5:32:18 PM PDT by UCANSEE2 ( If you think I'm crazy, just wait until you talk to my invisible friend.)
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To: Grams A

Can you make brain dead people unconscious? I’m not sure ketamine would have any effect on those fools.


19 posted on 10/06/2012 5:50:30 PM PDT by bigheadfred (wowza)
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To: kevslisababy

I hope he is recovering well.

And THANK him (from my family) for his service!


20 posted on 10/06/2012 5:52:21 PM PDT by bigheadfred (wowza)
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To: UCANSEE2

Since my chance of winning the lottery is reeeeally low, I think I’ll try the ketamine...Waiter!!!!


21 posted on 10/06/2012 5:54:32 PM PDT by bigheadfred (wowza)
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To: bigheadfred

I was thinking veterinary anesthetic (like for spays/ neuters), too.

What is wrong with the mental health community that instead of helping people come up with a way to resolve or deal with whatever is *making* them depressed (chemical causes excepted, of course), they drug them with stuff that often makes them worse (or adds other problems)?
Cope not dope (whenever possible).

(I’ve always thought that sedation for a day or 2 would help with quitting smoking)


22 posted on 10/06/2012 6:03:57 PM PDT by KGeorge
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To: bigheadfred

You also develop a taste for oats........


23 posted on 10/06/2012 6:08:52 PM PDT by ninonitti
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To: savagesusie
You seem to be decrying the 'a pill for every emotion/ache/pain' mindset that seems so prevalent these days.
And there's no doubt that over-medication causes myriad personal and societal problems - many unnecessarily - whether the 'prescription' comes from an MD or over the counter.
But then again, maybe it's merely our limited historical experience bearing on the question, as folks have been reaching for 'something' since time immemorial.

What I hope you're not saying is that clinical depression is simply a haywire emotion in need of God, or some electively dodgy behavior remedied only by same ?

Not trying to be argumentative, just attempting to reel us back in toward the original thread topic.

Depression is as real as a tumor eating one alive inside .. capable of robbing one of much hope of life-buoying optimism, or of seeing the sky in more than various shades of grey.

Is it over-diagnosed in our chronically excuse-making America ?
Most certainly, by many scammers of many flavors on both the doctor and patient sides of the prescription pad.

And horse tranquilizer does seem a bit much on first glance . . hopefully, time & legitimate research will tell the tale in the end.
Bread mold probably seemed an absurdly far-fetched candidate for reducing battlefield wound infection mortality . . .


(and that's about all the typing i intend doing this weekend .. LOL)

24 posted on 10/06/2012 6:10:39 PM PDT by tomkat
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To: savagesusie

Depression is a serious mental disorder and for some people suffering from it, chemicals which induce behavioral changes by directly influencing their brain are a saving grace, without which they would be too suicidal / disruptive to prevent themselves from being harmed, along with others. I have seen enough such cases in my life to know how many lives have been saved by anti-depressant medications.


25 posted on 10/06/2012 6:13:18 PM PDT by James C. Bennett (An Australian.)
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To: UCANSEE2
I might point out that winning the Lottery removes depression for as long as the money holds out.

Actually, I don't think that is true. Depression is more about brain chemistry than it is about external events.

26 posted on 10/06/2012 6:13:55 PM PDT by ladyjane
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To: ninonitti
You also develop a taste for oats........

With molasses. I can't stand oats without a litle molasses. But when I was a kid and into grandma's Gravy Train I definitely preferred that dry.

27 posted on 10/06/2012 6:21:37 PM PDT by bigheadfred (wowza)
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To: KGeorge

Someone else has pointed out they use it to paralyze horses before they castrate them. Seems like a good idea.


28 posted on 10/06/2012 6:23:34 PM PDT by bigheadfred (wowza)
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To: kevslisababy

God bless your son and those like him.


29 posted on 10/06/2012 6:31:16 PM PDT by jwalsh07 (.)
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To: tomkat

I use Soma, not for depression, but to help relieve the muscles surrounding two ruptured disks.

Is there something I should know about this drug?


30 posted on 10/06/2012 6:35:40 PM PDT by Jemian
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To: kevslisababy
My son was seriously injured in Afghanistan 18 months ago, and he was kept in a coma for 8 days with ketamine. I thought it was for the pain, since just about every bone in his lower back down to his toes was broken.

Whatever it was for, the outcome in the end was fine. But when he did come around, there were some very weird things coming out of his mouth!

I hope he has recovered completely. God bless him!

31 posted on 10/06/2012 6:36:28 PM PDT by arasina (Communism is EVIL. So there.)
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To: savagesusie

Whoa! You are the second person to mention Soma. That is not ketamine; it is carisoprodol. It doesn’t help depression, at least in me, nor does it cause it.

Is my research faulty?


32 posted on 10/06/2012 6:38:18 PM PDT by Jemian
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To: Jemian
No Jem, sorry for the confusion.

'Soma' was a cure-all sort of narcotic something or other given to the 'citizens' in Aldous Huxley's apocalyptic novel 'Brave New World'.

Here, from Wiki:

In the book, soma is a hallucinogen that takes users on enjoyable, hangover-free "holidays".
It was developed by the World State to provide these inner-directed personal experiences within a socially managed context of State-run 'religious' organizations; social clubs.
The hypnopaedically inculcated affinity for the State-produced drug, as a self-medicating comfort mechanism in the face of stress or discomfort,
  thereby eliminates the need for religion or other personal allegiances outside or beyond the World State.

33 posted on 10/06/2012 6:45:08 PM PDT by tomkat
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To: savagesusie

I must put my two cents in here.....
I have gone thru rough times, and thanks to the grace of God have not had the need for what I call ‘happy pills’.

Many of my friends have, and I have concerns for them.

They aren’t religious, and that is a HUGE component of one’s well being.

Get that settled and squared away, and THEN see if there is a need for meds.


34 posted on 10/06/2012 6:45:30 PM PDT by WildHighlander57 ((WildHighlander57 returning after lurking since 2000))
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To: bramps

I tried St John’s Wort when I had mild depression and concluded that it did not work at all.


35 posted on 10/06/2012 6:55:35 PM PDT by grumpa
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To: tomkat

Thank you for the clarification. Soma, carisoprodol, can be habit forming and I don’t take it regularly. But, I try to keep some with me constantly because my back pain is debilitating.

Now, you have found me out. I haven’t read Huxley and so wasn’t familiar with the context.

Thanks.


36 posted on 10/06/2012 6:56:52 PM PDT by Jemian
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To: WildHighlander57
Anti-depressants are not "happy pills." It is good that you have never needed psychotropic medication. Through the grace of God, scientists have compounded substances that correct biochemical disruptions. Years ago, people with some mental illnesses that can now be treated with medicine would have been hospital patients, raging alcoholics, or bodies in the morgue from suicide. Instead, they lead productive lives.

Would you tell a diabetic that they would not need insulin if they had a better relationship with the Lord? Or a cancer patient that they should just pray the pain away? Clinical depression differs from situational depression. It does not have to be triggered by events in one's life.

I am glad you never needed medication. I hope, to God, neither you nor anyone you love ever does.

37 posted on 10/06/2012 7:14:07 PM PDT by informavoracious (I am a Sedevacantist. I believe the chair is EMPTY.)
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To: grumpa
You need to take it for several weeks before it has an effect. And you MUST take the right dosage split up during the day. That's why I suggested the solaray brand that is meant to be taken twice a day (morning and night). Been using it for years. No side effects at all, and it does work for both sleep and mild depression.
38 posted on 10/06/2012 7:20:39 PM PDT by bramps
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To: Jemian

I ruptured one disk about 20 years ago. Pain worse than any sane person can imagine. I thought I was tough until this happened. Cried like a baby. God bless you having endured two.


39 posted on 10/06/2012 7:23:27 PM PDT by Private_Sector_Does_It_Better (I AM ANDREW BREITBART)
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To: bigheadfred
This is what they use to tranquilize horses, right? So a good dose removes depression for 10 days by rendering you unconscious for that period.

Actually, it works by restoring your equinimity:)

40 posted on 10/06/2012 7:40:02 PM PDT by Ken H
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To: kevslisababy

I’m so sorry to hear you son was injured. I hope he recovers quickly and does well. I appreciate his service.


41 posted on 10/06/2012 7:49:19 PM PDT by SaraJohnson
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To: James C. Bennett

My sister committed suicide so don’t tell me you KNOW how many lives were SAVED by anti-depressant medication. YOU don’t know. Scientists DON’T know. YOU GUESS. Scientists KNOW those drugs are TOXIC to the body and damages it. You can’t put toxins in the body with NO negative results. How many people have killed other people and themselves while ON medication. You leave that little tidbit out-—conveniently......kind of like the “evil of guns” argument——not counting the millions of lives saved by just having that “evil” gun.

True—there are some brains in need of medication-—but you can MEASURE that. MOST times, “depression” is the result of subjective analysis-—ALL physical examinations will not show up ANYTHING physical.

All the medical mumble jumble-—most problems—are either because of toxins in the body (probably from vaccinations)==which can be measured-—or inadequate diet and no exercise—or because of childhood trauma-—not dealing with fundamental issues of life—most likely character flaws.

BTW, science is all about assumptions-—most of which try to cover up all relevant symptoms so the doctors *SEEM* to *know* what they are talking about.

Now, I am not talking about all pills and doctors that deal with broken bones and such-—things which CAN be KNOWN. That is completely different.

I am talking about the fraudulent *science* of psychology. Most psychologists are quacks. Some are excellent-—but they *know* that they don’t know everything and they understand psychoanalysis and the power of the brain WITHOUT drugging it.

Only God removes fear and can replace it with *hope*. True—many times desperate people need help-—but pills only cover-up and delay the problem and damage the body in the meantime and create more problems and fears.

Have you *ever* counted all the pills that seniors take? I have-—it is staggering......been conditioned by the marketing.

My grandparents didn’t need any *medication* and they lived to be in their eighties and were active until their quick death. Of course, they were not filled with all the toxins from vaccinations and taking pills for aches and pains which collect in the body and they were active (farming) for most of their lives-—no GMO foods, corn syrup in everything, soda pop was rare, and they had non floridated water (well water).


42 posted on 10/06/2012 8:33:52 PM PDT by savagesusie (Right Reason According to Nature = Just Law)
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To: bigheadfred

Well, yeah, but :wince: (My grandmother grew up on a ranch. I’m workin’ on it, but still a city girl so far)


43 posted on 10/06/2012 8:43:10 PM PDT by KGeorge
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To: savagesusie
All the medical mumble jumble-—most problems—are either because of toxins in the body (probably from vaccinations)==which can be measured-—or inadequate diet and no exercise—or because of childhood trauma-—not dealing with fundamental issues of life—most likely character flaws

Only God removes fear and can replace it with *hope*.

Psychological problems run rampant in socialist societies. Or at least problems that people label "psychological".

Is it a coincidence that these are Godless societies? I think not.

When you attempt to remove God from society, hope dissipates ...societal and familial bonds are damaged and broken. Depression results. And psychologists make fortunes by attributing these problems to different causes.

I am amazed how many people can't figure this out.

44 posted on 10/06/2012 8:55:46 PM PDT by what's up
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To: Jemian
She is referring to a fictional drug from “Brave New World” I think. Not to the muscle relaxant which is (IMHO) a gift from God when there is a major weather system change.
45 posted on 10/06/2012 9:12:32 PM PDT by Harmless Teddy Bear (Fate plays chess and you don't find out until too late that he's been using two queens all along)
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To: ladyjane
Actually, I don't think that is true.

You may have a point there. If being 'rich' made people happy, then why do some many of the 'rich and famous' commit suicide in one way or another? Is it because material possessions aren't the key to happiness?

Depression is more about brain chemistry than it is about external events.

I agree that an imbalance in brain chemistry, or defect in it can cause depression. However, if one has no 'medical' problem, they can still be afflicted with depression. That type of depression usually comes from external events.

So... maybe the best answer is that we are both correct, and it depends on the person.

46 posted on 10/06/2012 9:48:29 PM PDT by UCANSEE2 ( If you think I'm crazy, just wait until you talk to my invisible friend.)
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To: Private_Sector_Does_It_Better

I have arranged things in my life that I can spend a significant portion of the time lying down. That keeps me fairly pain free and from needing drugs every day. I limit my activities to short bursts. I don’t go to sports events, concerts or hikes.

But I do a little gardening, go to church, and half-hour grocery shopping.

I am so glad Al Gore invented the internet, I would be stark-raving mad without it. Things could be much worse and there are many people in worse shape than me. I can manage.


47 posted on 10/06/2012 9:49:31 PM PDT by Jemian
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To: savagesusie
How many people have killed other people and themselves while ON medication.

The cdc says about 11% of the population takes antidepressants. And yet, the murder rate in the US has been steadily declining for the last 20+ years. It is as low now as it was in the early 1960s. Suicide rates have also fallen in the US, and were lower in 2005 than in 1950, 1960 and 1970.

I don't think you have much of a case.

____________________________________________________________

Sources:

http://www.npr.org/blogs/health/2011/10/20/141544135/look-around-1-in-10-americans-take-antidepressants

Suicide rates 1950-2005: http://www.infoplease.com/ipa/A0779940.html

Murder rates 1960-2010: http://www.disastercenter.com/crime/uscrime.htm

48 posted on 10/06/2012 10:22:43 PM PDT by Ken H
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To: Renfield

shock treatments were done for the exact same reason.....


49 posted on 10/06/2012 10:33:58 PM PDT by cherry
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To: Jemian
IIRC Soma was the drug of choice in the book "Brave New World".........

in moderan times, its a simple muscle relaxant....I'm not even sure how good.....naprosyn works better for me with all my arthritic joints and herniated discs as Lortab etc...

50 posted on 10/06/2012 10:38:02 PM PDT by cherry
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