Skip to comments.Bacteria in mouth may trigger colorectal cancer
Posted on 08/14/2013 9:15:28 PM PDT by TexGrill
WASHINGTON, Aug. 14 (Xinhua) -- U.S. researchers said Wednesday they have discovered how a common oral bacterium can trigger a cascade of changes leading to colorectal cancer.
The microorganism called fusobacteria, which are found in the mouth, may stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors, two studies published in the journal Cell Host & Microbe revealed.
Colorectal cancer is the second leading cause of cancer-related death in the United States. Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients but it was not known whether they directly contribute to the formation of tumors.
In one of the new studies, Professor Yiping Han from the Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called FadA, which is found on the surface of these bacterial cells, to attach to and invade human colorectal cancer cells.
FadA then turns on cancer growth genes and stimulates inflammatory responses in these cells and promotes tumor formation, Han said.
Han's team also found that the FadA gene levels are 10 to 100 times higher than normal in precancerous and malignant colon polyps. Moreover, they identified a compound known as peptide that can prevent FadA's effects on cancer cells.
"We showed that FadA is a marker that can be used for the early diagnosis of colorectal cancer and identified potential therapeutic targets to treat or prevent this common and debilitating disease," Han said.
(Excerpt) Read more at news.xinhuanet.com ...
Mucho thanks for the heads up. I’ll be 65 soon & my Dad once told me that sooner or later we guys are all going to check out either from prostate cancer or enlarged prostate.
I was just hoping to avoid further finger waves; the last one came from a retired BG, MC, Ret. working for OSHA who told me “you don’t enjoy getting a DR exam, you think I enjoy giving them!!?””
This was after he rammed the ol’ index finger where I least wanted it & I yelled, “OW!!! What are you doing up there, doc, TDY!!!?”
The needle he would fire through the rectal wall into your prostate 2 dozen times over the course of an hour will be worse than “OW”.
My dad had prostate cancer when he died, but he died of other causes. He told me he refused prostate surgery, because of the bad results a friend of his suffered from such surgery.
During my visit to my urologist last spring, he told me he had undergone a prostate biopsy recently, and apologized for bitching at me for flinching every time he fired the biopsy needle into my prostate during my two biopsies.
Thanks for the ping!
Biopsy needle? Geez...so much to look forward to in the `golden years’.
Just had my first colonoscopy but that was nothin’ in the hurt department. Open heart surgery wasn’t that big a deal either. Guess it’s back to my old Army doc whose name believe it or not is Dr. Cutting.
Better than Dr. Payne, I suppose.
My brother in law’s a doctor - his feeling is that lots of men get prostate cancer and they usually die of something else - something like old age...
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