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Bacteria in mouth may trigger colorectal cancer
Xinhua News Agency ^ | 08/15/2013 | Yang Yi

Posted on 08/14/2013 9:15:28 PM PDT by TexGrill

WASHINGTON, Aug. 14 (Xinhua) -- U.S. researchers said Wednesday they have discovered how a common oral bacterium can trigger a cascade of changes leading to colorectal cancer.

The microorganism called fusobacteria, which are found in the mouth, may stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors, two studies published in the journal Cell Host & Microbe revealed.

Colorectal cancer is the second leading cause of cancer-related death in the United States. Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients but it was not known whether they directly contribute to the formation of tumors.

In one of the new studies, Professor Yiping Han from the Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called FadA, which is found on the surface of these bacterial cells, to attach to and invade human colorectal cancer cells.

FadA then turns on cancer growth genes and stimulates inflammatory responses in these cells and promotes tumor formation, Han said.

Han's team also found that the FadA gene levels are 10 to 100 times higher than normal in precancerous and malignant colon polyps. Moreover, they identified a compound known as peptide that can prevent FadA's effects on cancer cells.

"We showed that FadA is a marker that can be used for the early diagnosis of colorectal cancer and identified potential therapeutic targets to treat or prevent this common and debilitating disease," Han said.

(Excerpt) Read more at news.xinhuanet.com ...


TOPICS: Business/Economy; Health/Medicine; Science; Society
KEYWORDS: bacteria; cancer; cancerbacteria; coloncancer; colorectalcancer; fada; fusobacteria; health; mouth
Just curious, is this one of those gay diseases?
1 posted on 08/14/2013 9:15:28 PM PDT by TexGrill
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To: TexGrill

Um, nope.


2 posted on 08/14/2013 9:20:51 PM PDT by headstamp 2 (What would Scooby do?)
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To: TexGrill

No, my FRiend. Colon cancer is a serious killer - I survived stage 3 after a lemon sized tumor was removed 6 years ago, had six months of chemo and serious complications that nearly killed me afterward. Nothing to do with the gay thing. It does run in families, my grandfather died from it. In my case, I got to see miracle healing and have the gift of more time with my family. Medical treatment has made great progress on this illness. I am very happy to be here and alive and participating in life!


3 posted on 08/14/2013 9:25:58 PM PDT by FlyingEagle
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To: FlyingEagle

Sorry to hear that. Good luck with your recovery.


4 posted on 08/14/2013 9:30:43 PM PDT by TexGrill (Don't mess with Texas)
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To: FlyingEagle

Glad you survived. On a related note, I wonder how many men have died from prostate cancer because they didn’t want their doctor’s finger up their butt for 3 seconds. I mean, really?


5 posted on 08/14/2013 9:41:01 PM PDT by Lizavetta
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To: Lizavetta

Don’t need to go to the doctor for that anymore. TSA has people that do that.


6 posted on 08/14/2013 9:43:38 PM PDT by Cold Heart
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To: Lizavetta

OK, real question: after getting the rectal finger wave for years in the military, can I now count on the PSA test to replace the undignified invasive prostate exam?


7 posted on 08/14/2013 9:48:04 PM PDT by elcid1970 ("The Second Amendment is more important than Islam.")
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To: TexGrill

Bacteria in colon may trigger mouth cancer


8 posted on 08/14/2013 9:49:45 PM PDT by bunkerhill7 (("The Second Amendment has no limits on firepower"-NY State Senator Kathleen A. Marchione.))
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To: Lizavetta

Hadn’t thought about it before, but some contemporary doctors have been acting a little weird. ;-)


9 posted on 08/14/2013 9:54:38 PM PDT by familyop (We Baby Boomers are croaking in an avalanche of rotten politics smelled around the planet.)
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To: TexGrill
“Just curious, is this one of those gay diseases”

Nope it killed my mother and several others in the family...

I suspect you comment is supposed to be funny but it illustrates how out of touch so called conservatives are with the real world.

I'm becoming more convinced every day that Conservatism is not winning elections because Conservative voters only listen to talk radio (15% tops of the electorate) Fox (geezers over 65) and blogs like this which are so often just an echo chamber of the same folks saying the same thing year after year..

IMHO the problem is the messengers not the message. We have lost the battle of the message by failing to recognize personality is what wins an election in today's America.

The vast majority of those here and conservatives in general have squandered what little political capital they had left by attacking O and the Dims personally. Face it, folks like O and the Dims better than they like conservatives at this point in time.

The fools in Washington of both parties can continue to play the day to day game of patty cake but the country as a whole has simply tuned them out. The electorate here is becoming much like the third world in that they have long since concluded that the politicians have nothing to say that matters in their lives and are useless... America's greatness was based on our ability to do big things and we simply no longer have the political leaders capable of even deciding to get out of bed in the morning let alone conceiving of any "big" idea that could possibly benefit the country..the name of the game for all politicians is get mine while I can.

10 posted on 08/14/2013 9:57:49 PM PDT by montanajoe
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To: familyop

try some probiotics everyday


11 posted on 08/14/2013 9:58:31 PM PDT by acapesket
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To: montanajoe

So let’s go ahead throw in the towel and bow down Hillary.


12 posted on 08/14/2013 10:02:14 PM PDT by TexGrill (Don't mess with Texas)
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To: elcid1970

No. Do both. What the prostate feels like is important too.


13 posted on 08/14/2013 10:02:17 PM PDT by Lizavetta
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To: elcid1970

Maybe I’m jaded. After four children and my midwife’s hands in undignified places for legitimate reasons, it doesn’t bother me any more.


14 posted on 08/14/2013 10:04:58 PM PDT by Lizavetta
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To: TexGrill; montanajoe
Angry old man doesn't win elections

Inspiration and positive messages win elections:


15 posted on 08/14/2013 10:07:07 PM PDT by MrShoop
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To: montanajoe

You just reiterated Jason Lewis’s rant from today.


16 posted on 08/14/2013 10:23:57 PM PDT by miliantnutcase
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To: montanajoe; Jim Robinson
I suspect you comment is supposed to be funny but it illustrates how out of touch so called conservatives are with the real world.

Sell your tripe at DU. Obozo's policies and agenda is what has been"attacked, NOT his skin color. Obozo isn't "loved" for his personality, which is contrived! He's "loved" for the false promise he brought!

17 posted on 08/14/2013 10:33:10 PM PDT by SoldierDad (Proud dad of an Army Soldier who has survived 24 months of Combat deployment.)
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To: Lizavetta

If my doctor doesn’t give me 5, I pout for three days.

... KIDDING ! JUST KIDDING!


18 posted on 08/14/2013 10:39:30 PM PDT by dr_lew
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To: dr_lew

Nothing but the choicest rotten tomatoes for you!


19 posted on 08/14/2013 11:16:07 PM PDT by HiTech RedNeck (The Lion of Judah will roar again if you give him a big hug and mean it. See my page.)
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To: Lizavetta
it doesn’t bother me any more.

Same here, after 10 children. I had a colonoscopy with no anesthesia ... just a little labor breathing and a motherly nurse patting my hand.

Get your colonoscopy, everyone. Dying of colon cancer is bad.

(This Public Service Announcement is offered in memory of Congressman Billybob.)

20 posted on 08/15/2013 2:33:02 AM PDT by Tax-chick (Ask me about the Weiner Wager. Support Free Republic!)
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To: TexGrill

I wonder if the bacteria mentioned in the article is associated with gum disease. My dentist often mentions that gum disease contributes to a variety of serious health problems.


21 posted on 08/15/2013 2:34:32 AM PDT by Tax-chick (Ask me about the Weiner Wager. Support Free Republic!)
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To: montanajoe

Here’s a Rino you will learn to appreciate:

http://amarillo.com/blog-post/enrique-rangel/2013-08-13/something-unusual-abbott-sides-dojs-challenge-merger-between-0


22 posted on 08/15/2013 3:00:39 AM PDT by TexGrill (Don't mess with Texas)
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To: montanajoe

That’s BS. We’re winning all kinds of elections. We’re winning at all levels except one office at Pennsylvania ave. Conservatives have as a big a foot print today in state governments than we’ve ever had, and we’ve controlled the House for all but four years of the last two decades.


23 posted on 08/15/2013 3:23:10 AM PDT by ilgipper (Obama is proving that very bad ideas can be wrapped up in pretty words)
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To: bunkerhill7
Bacteria in colon may trigger mouth cancer

Close, but no cigar

24 posted on 08/15/2013 4:21:28 AM PDT by SC DOC
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To: montanajoe

Have fun here @ FR where, unlike virtually every “progressive” site on the web, you won’t get immediately banned for ingsoc unbellyfeel.


25 posted on 08/15/2013 5:13:20 AM PDT by SecondAmendment (Restoring our Republic at 9.8357x10^8 FPS)
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To: SC DOC
The last surviving passenger from the Hindenburg passed away today.

She was 102.

She injured her leg when she jumped from the burning Zeppelin inferno.

She had to use a cane for the rest of her life

coz she always walked with a blimp.

26 posted on 08/15/2013 6:38:28 AM PDT by bunkerhill7 (("The Second Amendment has no limits on firepower"-NY State Senator Kathleen A. Marchione.))
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To: Tax-chick
My doctor told me years ago to gargle with hydrogen peroxide every day after I brush my teeth.
27 posted on 08/15/2013 6:48:47 AM PDT by Ditter
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To: Ditter

That’s rather unnngh, but it would kill germs!


28 posted on 08/15/2013 6:51:37 AM PDT by Tax-chick (Ask me about the Weiner Wager. Support Free Republic!)
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To: Tax-chick
Yes, that was his point and very soon the taste doesn't bother you. My doctor said he did it every day. Also my dermatologist said to put a little bit of Bactroban (antibiotic cream) up each nostril several times a week to control bacteria in your nostrils.
29 posted on 08/15/2013 6:59:42 AM PDT by Ditter
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To: Ditter

I use tea-tree oil to prevent ear infections.

Did the hydrogen peroxide discolor your teeth?


30 posted on 08/15/2013 7:20:47 AM PDT by Tax-chick (Ask me about the Weiner Wager. Support Free Republic!)
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To: Tax-chick

No.


31 posted on 08/15/2013 7:55:15 AM PDT by Ditter
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To: Tax-chick

Mine is scheduled for next month. Second time around. The procedure, in itself, isn’t bad; it’s the preceding 24 hours that suck.


32 posted on 08/15/2013 8:01:23 AM PDT by Hoffer Rand (There ARE two Americas: "God's children" and the tax payers)
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To: Tax-chick
I meant to add, I forget to gargle every day but I always gargle with hydrogen peroxide if I feel a sore throat starting. It makes a huge difference. If I catch a cold I gargle with HP and I wash my sinuses out with warm salt water using my Neti Pot at least 3 times a day.

It will keep me from having a sinus infection. I always ended up with a sinus infection after a cold and the infection would finally sent me to the doctor for antibiotics. I have not had a sinus infection for several years, ever since I started using my Neti Pot.

33 posted on 08/15/2013 8:02:19 AM PDT by Ditter
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To: Hoffer Rand
it’s the preceding 24 hours that suck

And that's the truth! I have almost 2 years to the next one.

34 posted on 08/15/2013 8:04:55 AM PDT by Tax-chick (Ask me about the Weiner Wager. Support Free Republic!)
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To: ilgipper
The GOP may be winning some elections but Conservatives are not..

Sorry I don't equate the GOP with Conservatives.

35 posted on 08/15/2013 9:22:41 AM PDT by montanajoe
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To: montanajoe
The GOP may be winning some elections but Conservatives are not..

Sorry I don't equate the GOP with Conservatives.

I agree with your second statement, but not the first. It is conservatives who are winning. 2010 was a conservative wave. 2012 was a Republican bungling. The Republicans react to polling and act weak to be nice. Conservatives are making a case for another direction. We have conservative governors all over the country, some in blue states like WI. We have conservatives taking over statehouses, winning Congressional seats and Senate seats. Five years ago we had DeMint and a few occasional good conservatives in the Senate. Today we have a conservative coalition leading the way.

36 posted on 08/15/2013 2:50:52 PM PDT by ilgipper (Obama is proving that very bad ideas can be wrapped up in pretty words)
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To: Tax-chick; Swordmaker
"My dentist often mentions that gum disease contributes to a variety of serious health problems."

This is a must-read thread from 2011. I've studied it multiple times. Somewhere in the middle of it, another Freeper with a biochem background shows up and attempts to bash the whole thing; he was not successful IIRC.

http://www.freerepublic.com/focus/f-chat/2769347/posts

Toothbrush no longer enters my mouth unless it's loaded with baking soda.

37 posted on 08/15/2013 8:53:18 PM PDT by oprahstheantichrist (The MSM is a demonic stronghold, PLEASE pray accordingly - 2 Corinthians 10:3-5)
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To: montanajoe

Winner! Nice rant.


38 posted on 08/15/2013 8:57:13 PM PDT by mad_as_he$$
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To: neverdem

Ping....


39 posted on 08/15/2013 8:59:24 PM PDT by oprahstheantichrist (The MSM is a demonic stronghold, PLEASE pray accordingly - 2 Corinthians 10:3-5)
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To: elcid1970

The PSA is worse than the “probe”. A high reading from a PSA test will probably result in a much more invasive and worthless prostate biopsy.

My urologist put me through two of those (they are very lucrative for him), that he claimed showed some “suspicious cells”. When I refused a third one, he admitted that was reasonable, considering my age and other medical factors.

I knew he wanted the $3,000 fee for the exam, but he admitted if the exam disclosed cancer, treatment might not be advised.


40 posted on 08/15/2013 9:33:34 PM PDT by tdscpa
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To: tdscpa

Mucho thanks for the heads up. I’ll be 65 soon & my Dad once told me that sooner or later we guys are all going to check out either from prostate cancer or enlarged prostate.

I was just hoping to avoid further finger waves; the last one came from a retired BG, MC, Ret. working for OSHA who told me “you don’t enjoy getting a DR exam, you think I enjoy giving them!!?””

This was after he rammed the ol’ index finger where I least wanted it & I yelled, “OW!!! What are you doing up there, doc, TDY!!!?”


41 posted on 08/15/2013 9:44:35 PM PDT by elcid1970 ("The Second Amendment is more important than Islam.")
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To: elcid1970

The needle he would fire through the rectal wall into your prostate 2 dozen times over the course of an hour will be worse than “OW”.

My dad had prostate cancer when he died, but he died of other causes. He told me he refused prostate surgery, because of the bad results a friend of his suffered from such surgery.

During my visit to my urologist last spring, he told me he had undergone a prostate biopsy recently, and apologized for bitching at me for flinching every time he fired the biopsy needle into my prostate during my two biopsies.


42 posted on 08/15/2013 10:05:38 PM PDT by tdscpa
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To: oprahstheantichrist

Thanks for the ping!


43 posted on 08/15/2013 10:23:27 PM PDT by neverdem (Register pressure cookers! /s)
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To: oprahstheantichrist; Black Agnes; TexGrill
Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

44 posted on 08/15/2013 11:28:42 PM PDT by neverdem (Register pressure cookers! /s)
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To: oprahstheantichrist

Thanks!


45 posted on 08/16/2013 2:49:53 AM PDT by Tax-chick (Ask me about the Weiner Wager. Support Free Republic!)
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To: tdscpa

Biopsy needle? Geez...so much to look forward to in the `golden years’.

Just had my first colonoscopy but that was nothin’ in the hurt department. Open heart surgery wasn’t that big a deal either. Guess it’s back to my old Army doc whose name believe it or not is Dr. Cutting.

Better than Dr. Payne, I suppose.


46 posted on 08/16/2013 5:28:47 AM PDT by elcid1970 ("The Second Amendment is more important than Islam.")
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To: elcid1970

My brother in law’s a doctor - his feeling is that lots of men get prostate cancer and they usually die of something else - something like old age...


47 posted on 08/23/2013 4:02:34 AM PDT by GOPJ (- - NSA - The only part of government that actually listens...Joe Kovacs)
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