Denying the eternal significance of human response renders the whole Bible meaningless.
I don’t deny human response at all, but the Bible teaches that human response is the response to the gift of faith. No man on his on seeks God. Indeed Christ said no man can come to Him (no man has the ability in his natural state) unless the Father draws him. Regeneration precedes our human response. In other words, a genuine human response to the real Jesus of the Bible is evidence of what He has already done for and in a sinner.