They are mutually exclusive. There is monergism which believes God does the work. This is usually identified by Reformers and was the view of the early church. And there is synergism which believes that it takes man's cooperation to some degree. This is probably 90% of what the churches believe to day to varying degrees. Synergism is wrong.
There is no reasonable way to read that except Jesus saying those who had a choice over and over again would not choose God's way. Not because they had no choice but to defy God but because they chose contrary to what God wanted for them.