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Is John 6:66 Evidence of Transubstantiation?
I don't know, but Genesis 2:7 is.

I don't think that it's the same thing. When God formed the first man out of the dust of the earth (of which He created from nothing in the first place) and breathed into him the breath of life and man became a living soul, this was God creating something totally new, not taking something of one substance and changing it into a completely different substance. I recall reading about how our physical bodies are remarkably like the dust of the earth in mineral content. We ARE carbon life forms after all.

In the sweat of thy face shalt thou eat bread, till thou return unto the ground; for out of it wast thou taken: for dust thou art, and unto dust shalt thou return. (Gen. 3:19)

A subset, perhaps. Unleavened bread is symbolic. That God, in creating man, changes lifeless matter into human flesh by breathing upon it is clear.

That in recreating man (the new Adam) God would change unleavened bread into human flesh by breathing on it is no scandal. Jesus is the New Adam, thus the act of Creation anew. Jesus the man was sinless, thus the unleavened bread.

God couldn't recreate man of the dust again, for the dust along with all creation has been defiled. It took Jesus in body, blood, soul and divinity to redeem creation. Amen!

"For my flesh is real food and my blood is real drink."