Well, according to Bible text, a man not authorized to touch it reached to steady it when it was about to topple over, and he was ‘struck down, instantly’. The Philistines were imedaitely struck with a ‘plague’ when they went to open it after caturing it in battle with the Israelites, s they left it sitting out for years and years and it was eventually towed by oxen back to Jerusalem (where the man reached to steady it on the journey).
2 Samuel 6
6 And when they came to Nachon’s threshingfloor, Uzzah put forth his hand to the ark of God, and took hold of it; for the oxen shook it.
7 And the anger of the LORD was kindled against Uzzah; and God smote him there for his error; and there he died by the ark of God.