Closing the circle would be like perpetual motion, it is disallowed. Energy comes from the Sun and 'Enzymes' come from the environment. A good example would be that ATP cycle.
It is disallowed by the Newtonian Paradigm. But in the Newtonian Paradigm, everything is assumed to be a mechanism, a "simple" closed system. The type of closure involved in what Rosen is doing is a logical closure that does two things: (1) It obviates problems of infinite regress; (2) it helps to elucidate how living systems instantiate causal entailments beyond those available to mechanisms and machines.
Anyhoot, Rosen has written a couple of enormously powerful books, potential "game changers." I suspect you would find his ideas of great interest LeGrande.