[[The point was that the prion contains no message (DNA, RNA) and is not autonomous to the molecular machine. Under the Shannon model, it would a type of “noise.”
In sum, when the prion is introduced into the communication - it causes malfunctions either in the channel or decoding, e.g. blocking the successful communication of beneficial messages perhaps as you say by causing other proteins to misfold.]]
and here again we see the importance of metainfo- species specific metainfo controlling, directing, allowing or dissallowing change- all withint species specific parameters.
The changes that would have had to occure for macroevolution would have included introducing, not just simplistic /micro-changes accumulating harmlessly, that had no apparent effect on the species, but would out of necessity had to include drastic changes to bring about hte morphological and biological changes that would move a species beyond it’s own kind- even gradually this would have presented a HUGE problem for hte speices, and would have proven deadly, as htese changes woudl have broken the boundaries of allowable microevolutionary change, and would have affected many many systems and subsystems, and would not have had rthe proper metainfo to deal with al lthese changes- to control htem, intigrate them, coordinate, and utilize htem for hte preservation of the species. The info to do so would simply have been non existent- We know htis from experiments and breedign programs.