they require being acted on- the act isnt the change- nor is it the information being changed, cells are predesigned just as I described in previous posts and show anticipation especially when many systems are affected and have info triggered that goes on to trigger other infos etc.
Not sure what you’re not understandign about htis?
Changes in the ability to metabolize new food sources, such as nylon, requires mutation.
If you have a source that says otherwise, please provide a link.
If you have an example of a new metabolc function arising without an associated mutation, please cite your source.