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Nope. Don't matter.

We know that it would look like bread and wine under the tests.

But its real substance is the Body and Blood.

Every now and then, though, something like this happens:

The miracle occurred on Easter Sunday, March 31, 1331, at the first Mass of the day, which was offered by Hugues de la Baume, the vicar of Blanot. Because of the solemn occasion, two men of the parish named Thomas Caillot and Guyot Besson were also serving in addition to the altar boys. At Communion time the two men approached the altar railing, took their places at each end and turned the long cloth over the railing. The parishioners took their places, held their hands under the cloth and waited for the approach of the priest.

One of the last to receive was a woman named Jacquette, described as being the widow of Regnaut d'Effour. The priest placed the Host on her tongue, turned, and started walking toward the altar. It was then that both men and a few of the communicants saw the Host fall from the woman's mouth and land upon the cloth that covered her hands. As the priest was then placing the ciborium inside the tabernacle, Thomas Caillot approached the altar and informed him of the accident. The priest immediately left the altar and approached the railing; but instead of finding the Host, he saw a spot of blood the same size as the Host, which had apparently dissolved into blood.

When the Mass was completed, the priest took the cloth into the sacristy and placed the stained area in a basin filled with clear water. After washing the spot and scrubbing it with his fingers numerous times he found that, far from becoming smaller and lighter, it had actually become larger and much darker. On removing the cloth from the basin he was surprised to find that the water had turned bloody. The priest and his assistants were not only astonished, but also frightened, and exclaimed, "This is the Precious Blood of our Lord Jesus Christ!" The priest then took a knife and, after washing it, cut from the cloth the piece bearing the bloody imprint of the Host. This square piece of cloth was reverently placed in the tabernacle.

http://www.therealpresence.org/eucharst/mir/blanot.html

Or this:

In 1263 a German priest, Peter of Prague, stopped at Bolsena while on a pilgrimage to Rome. He is described as being a pious priest, but one who found it difficult to believe that Christ was actually present in the consecrated Host. While celebrating Holy Mass above the tomb of St. Christina (located in the church named for this martyr), he had barely spoken the words of Consecration when blood started to seep from the consecrated Host and trickle over his hands onto the altar and the corporal.

The priest was immediately confused. At first he attempted to hide the blood, but then he interrupted the Mass and asked to be taken to the neighboring city of Orvieto, the city where Pope Ur ban IV was then residing.

The Pope listened to the priest's account and absolved him. He then sent emissaries for an immediate investigation. When all the facts were ascertained, he ordered the Bishop of the diocese to bring to Orvieto the Host and the linen cloth bearing the stains of blood. With archbishops, cardinals and other Church dignitaries in attendance, the Pope met the procession and, amid great pomp, had the relics placed in the cathedral. The linen corporal bearing the spots of blood is still reverently enshrined and exhibited in the Cathedral of Orvieto.

http://www.therealpresence.org/eucharst/mir/bolsena.html

Or this:

Dr. Edoardo Linoli says he held real cardiac tissue in his hands, when some years ago he analyzed the relics of the Eucharistic miracle of Lanciano, Italy.

The phenomenon dates back to the eighth century. A Basilian monk, who had doubts about the real presence of Christ in the sacred species, was offering Mass, in a church dedicated to St. Legontian in the town of Lanciano.

When he pronounced the words of the consecration, the host was miraculously changed into physical flesh and the wine into physical blood.

Later the blood coagulated and the flesh remained the same. These relics were kept in the cathedral.

Linoli, a professor of anatomy and pathological histology, and of chemistry and clinical microscopy, and former head of the Laboratory of Pathological Anatomy at the Hospital of Arezzo, is the only doctor who has analyzed the relics of the miracle of Lanciano. His findings have stirred interest in the scientific world.

At the initiative of Archbishop Pacifico Perantoni of Lanciano, and of the provincial minister of the Franciscan Conventuals of Abruzzo, and with authorization from Rome, in November 1970 the Franciscans of Lanciano decided to have the relics examined scientifically.

Linoli was entrusted with the study. He was assisted by Dr. Ruggero Bertelli, retired professor of human anatomy at the University of Siena.

Linoli extracted parts of the relics with great care and then analyzed the remains of "miraculous flesh and blood." He presented his findings on March 4, 1971.

His study confirmed that the flesh and blood were of human origin. The flesh was unequivocally cardiac tissue, and the blood was of type AB.

http://www.zenit.org/english/visualizza.phtml?sid=70440

Or this:

So it was that on August 14, 1730, during devotions for the vigil of the feast, while most of the Sienese population and the clergy of the city were attending these services, thieves entered the deserted Church of St. Francis. Taking advantage of the friars' absence, they made for the chapel where the Blessed Sacrament was kept, picked the lock to the tabernacle and carried away the golden ciborium containing consecrated Hosts.

The theft went undiscovered until the next morning, when the priest opened the tabernacle at the Communion of the Mass. Then later, when a parishioner found the lid of the ciborium lying in the street, the suspicion of sacrilege was confirmed. The anguish of the parishioners forced the cancellation of the traditional festivities for the feast of Our Lady's Assumption. The Archbishop ordered public prayers of reparation, while the civil authorities began a search for the consecrated Hosts and for the scoundrel who had taken them.

Two days later, on August 17, while praying in the Church of St. Mary of Provenzano, a priest's attention was directed to something white protruding from the offering box attached to his prie dieu. Realizing that it was a Host, he informed the other priests of the church, who in turn notified the Archbishop and the friars of the Church of St. Francis.

When the offering box was opened, in the presence of local priests and the representative of the Archbishop, a large number of Hosts were found, some of them suspended by cobwebs. The Hosts were compared with some unconsecrated ones used in the Church of St. Francis, and proved to be exactly the same size and to have the same mark of the irons upon which they were baked. The number of Hosts corresponded exactly to the number the Franciscan friars had estimated were in the ciborium -- 348 whole Hosts and six halves.

Since the offering box was opened but once a year, the Hosts were covered with the dust and debris that had collected there. After being carefully cleaned by the priests, they were enclosed in a ciborium and placed inside the tabernacle of the main altar of the Church of St. Mary. The following day, in the company of a great gathering of townspeople, Archbishop Alessandro Zondadari carried the Sacred Hosts in solemn procession back to the Church of St. Francis.

During the two centuries that followed it has sometimes been wondered why the Hosts were not consumed by a priest during Mass, which would have been the ordinary procedure in such a case. While there is no definite answer, there are two theories. One explanation is that crowds of people from both Sienna and neighboring cities gathered in the church to offer prayers of reparation before the sacred particles, forcing the priests to conserve them for a time. The other reason the priests did not consume them might well have been because of their soiled condition. While the Hosts were superficially cleaned after their discovery, they still retained a great deal of dirt. In such cases it is not necessary to consume consecrated Hosts, but it is permitted to allow them to deteriorate naturally, at which time Christ would no longer be present.

To the amazement of the clergy, the Hosts did not deteriorate, but remained fresh and even retained a pleasant scent. With the passage of time the Conventual Franciscans became convinced that they were witnessing a continuing miracle of preservation.

Fifty years after the recovery of the stolen Hosts, an official investigation was conducted into the authenticity of the miracle. The Minister General of the Franciscan Order, Father Carlo Vipera, examined the Hosts on April 14, 1780, and upon tasting one of them he found it fresh and incorrupt. Since a number of the Hosts had been distributed during the preceding years, the Minister General ordered that the remaining 230 particles be placed in a new ciborium and forbade further distribution.

A more detailed investigation took place in 1789 by Archbishop Tiberio Borghese of Sienna with a number of theologians and other dignitaries. After examining the Hosts under a microscope, the commission declared that they were perfectly intact and showed no sign of deterioration. The three Franciscans who had been present at the previous investigation, that of 1780, were questioned under oath by the Archbishop. It was then reaffirmed that the Hosts under examination were the same ones stolen in 1730.

As a test to further confirm the authenticity of the miracle, the Archbishop, during this 1789 examination, ordered several unconsecrated hosts to be placed in a sealed box and kept under lock in the chancery office. Ten years later these were examined and found to be not only disfigured, but also withered. In 1850, 61 years after they were placed in a sealed box, these unconsecrated hosts were found reduced to particles of a dark yellow color, while the consecrated Hosts retained their original freshness.

http://www.therealpresence.org/eucharst/mir/siena.html

These things still happen. I know a priest who had something like this happen to him, too, although the local bishop didn't want to make much of it either.

In a day where people are uncomfortable that supernatural things can happen, there is a lot of disbelief, but that's like how Thomas Hardy chose to refuse to believe in God even
though he wrote about how he longed for God to give him a sign that he existed. The signs are there. People may choose to think they're hokey,and that's ok for them, I guess, but some of us are happy to say, "Thank you, Jesus" for what he has shown us.